MeSH Browser

MeSH Heading: cGAS-STING Signaling Pathway
Tree Number(s): G02.111.820.926; G04.835.926
Unique ID: D000099196
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099196
Scope Note: A signal transduction pathway that involves cGMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream signaling adaptors. This pathway plays an essential role in the innate immune system by activating immune defenses, particularly against invading pathogens or harmful damage.
Entry Term(s): (cGAS-STING) Pathway; cGAS-STING Activation; cGAS-STING Immunity Pathway; cGAS-STING Innate Immunity Pathway; cGAS-STING Signaling; cGAS-STING cascade; cGAS–STING Cytosolic DNA Sensing Pathway
Previous Indexing: Signal Transduction (2015-2025)
Public MeSH Note: 2026
History Note: 2026
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M000768905
Scope Note: A signal transduction pathway that involves cGMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream signaling adaptors. This pathway plays an essential role in the innate immune system by activating immune defenses, particularly against invading pathogens or harmful damage.
Terms: cGAS-STING Signaling Pathway Preferred Term
Term UI T001149352
Date07/17/2025
LexicalTag NON
ThesaurusID NLM (2026); (cGAS-STING) Pathway
Term UI T001149165
Date06/25/2025
LexicalTag NON
ThesaurusID NLM (2026); cGAS-STING cascade
Term UI T001149167
Date06/25/2025
LexicalTag NON
ThesaurusID NLM (2026); cGAS-STING Signaling
Term UI T001149166
Date06/25/2025
LexicalTag NON
ThesaurusID NLM (2026); cGAS–STING Cytosolic DNA Sensing Pathway
Term UI T001147888
Date04/04/2025
LexicalTag NON
ThesaurusID NLM (2026)

cGAS-STING Signaling Pathway MeSH Descriptor Data 2026