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5-Aminolevulinate Synthetase MeSH Descriptor Data 2023


MeSH Heading
5-Aminolevulinate Synthetase
Tree Number(s)
D08.811.913.050.276
Unique ID
D000624
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000624
Scope Note
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Entry Term(s)
5-Aminolevulinate Synthase
Aminolevulinic Acid Synthetase
delta-Aminolevulinate Synthase
delta-Aminolevulinic Acid Synthetase
Registry Number
EC 2.3.1.37
Related Numbers
9037-14-3
CAS Type 1 Name
Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)
Previous Indexing
Acyltransferases (1966-1971)
Public MeSH Note
98; see AMINOLEVULINIC ACID SYNTHETASE 1972-97
History Note
98(72)
Date Established
1973/01/01
Date of Entry
1999/01/01
Revision Date
2007/07/09
5-Aminolevulinate Synthetase Preferred
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