MeSH Browser

MeSH Heading: ATP Citrate (pro-S)-Lyase
Tree Number(s): D08.811.913.050.331
Unique ID: D001275
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001275
Scope Note: An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
Entry Term(s): ATP Citrate (pro-3S)-Lyase; ATP Citrate Lyase; ATP Citrate Synthase; ATP-Dependent Citrate Lyase; Citrate Cleavage Enzyme
Registry Number: EC 2.3.3.8
Related Numbers: 9027-95-6
CAS Type 1 Name: ATP:citrate oxaloacetate-lyase ((pro-S)-CH2COO(-)--acetyl-CoA) (ATP-dephosphorylating)
Previous Indexing: Lyases (1966-1972)
Public MeSH Note: 98; see ATP CITRATE LYASE 1977-97; see KETOACID-LYASES 1973-76
History Note: 98(73)
Date Established: 1977/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0001918
Registry Number: EC 2.3.3.8
Related Numbers: 9027-95-6
Scope Note: An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
Terms: ATP Citrate (pro-S)-Lyase Preferred Term
Term UI T003794
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1973); Citrate Cleavage Enzyme
Term UI T003793
Date03/24/1976
LexicalTag NON
ThesaurusID UNK (19XX); ATP Citrate Synthase
Term UI T638309
Date04/28/2005
LexicalTag ABX
ThesaurusID NLM (2006); ATP-Dependent Citrate Lyase
Term UI T003792
Date11/20/1980
LexicalTag NON
ThesaurusID UNK (19XX); ATP Citrate (pro-3S)-Lyase
Term UI T003790
Date12/06/1982
LexicalTag NON
ThesaurusID UNK (19XX); ATP Citrate Lyase
Term UI T003791
Date11/18/1996
LexicalTag NON
ThesaurusID NLM (1998)

ATP Citrate (pro-S)-Lyase MeSH Descriptor Data 2023