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2-Isopropylmalate Synthase MeSH Descriptor Data 2023


MeSH Heading
2-Isopropylmalate Synthase
Tree Number(s)
D08.811.913.050.614
Unique ID
D015079
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015079
Scope Note
An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.
Entry Term(s)
alpha-Isopropylmalate Synthase
Registry Number
EC 2.3.3.13
Related Numbers
9030-98-2
CAS Type 1 Name
3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
Previous Indexing
Ketoacid-Lyases (1973-1974)
Ketoacids (1973-1974)
Malates (1973-1974)
Public MeSH Note
91; was see under KETOACID-LYASES 1975-90
History Note
91(75); was see under KETOACID-LYASES 1975-90
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2005/06/30
2-Isopropylmalate Synthase Preferred
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