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Antibody Diversity MeSH Descriptor Data 2023

MeSH Heading
Antibody Diversity
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Scope Note
The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
Entry Term(s)
Germ Line Theory
NLM Classification #
QW 541
Previous Indexing
Antibodies (1966-1969)
Antibody Specificity (1970-1979)
Public MeSH Note
History Note
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Antibody Diversity Preferred
Germ Line Theory Narrower
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