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Genetic Heterogeneity MeSH Descriptor Data 2023


MeSH Heading
Genetic Heterogeneity
Tree Number(s)
G05.365.331
Unique ID
D018740
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018740
Scope Note
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Entry Version
GENET HETEROGENEITY
Entry Term(s)
Heterogeneity, Genetic
Public MeSH Note
95
History Note
95
Date Established
1995/01/01
Date of Entry
1994/04/19
Revision Date
2008/07/08
Genetic Heterogeneity Preferred
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