MeSH Browser

MeSH Heading: Cystathionine beta-Synthase
Tree Number(s): D08.811.520.241.300.200
Unique ID: D003541
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003541
Annotation: /defic: consider also HOMOCYSTINURIA or HYPERHOMOCYSTEINEMIA
Scope Note: A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
Entry Term(s): Cystathionine Synthetase; Serine Sulfhydrase; beta-Thionase
Related Numbers: 9023-99-8
CAS Type 1 Name: L-Serine hydro-lyase (adding homocysteine)
Previous Indexing: Homocysteine (1973-1974); Hydro-Lyases (1973-1974); Serine (1973-1974)
See Also: Homocystinuria
Public MeSH Note: 1991; see HYDRO-LYASES 1975-1990
History Note: 1991(1975)
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0005533
Related Numbers: 9023-99-8
Scope Note: A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
Terms: Cystathionine beta-Synthase Preferred Term
Term UI T010268
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); beta-Thionase
Term UI T010267
Date05/18/1976
LexicalTag NON
ThesaurusID UNK (19XX); Cystathionine Synthetase
Term UI T010269
Date03/28/1983
LexicalTag NON
ThesaurusID UNK (19XX); Serine Sulfhydrase
Term UI T010270
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Cystathionine beta-Synthase MeSH Descriptor Data 2025