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An enzyme that catalyzes reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydroxyacyl-CoA. It plays a role in the oxidation of fatty acids and in mitochondrial fatty acid synthesis, has broad specificity, and is most active with crotonyl-CoA. EC 4.2.1.17.
Entry Term(s)
3-Hydroxyacyl CoA Hydrolyases
3-Hydroxyacyl Dehydratases
Crotonase
Enoyl CoA Hydratases
Enoyl Hydrase
beta-Hydroxyacyl Dehydratases
beta-Hydroxyacyl-CoA Dehydrases
trans-2-Enoyl-Coenzyme A Hydratase
Registry Numbers
EC 4.2.1.17
Related Numbers
9027-13-8
CAS Type 1 Name
(3S)-3-Hydroxyacyl-CoA hydro-lyase
Previous Indexing
Coenzyme A (1966-1977)
Hydro-Lyases (1966-1977)
Public MeSH Note
97; was ENOYL COA HYDRATASES 1978-96 (see under HYDRO-LYASES 1978-90)
History Note
97; was ENOYL COA HYDRATASES 1978-96 (see under HYDRO-LYASES 1978-90)
An enzyme that catalyzes reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydroxyacyl-CoA. It plays a role in the oxidation of fatty acids and in mitochondrial fatty acid synthesis, has broad specificity, and is most active with crotonyl-CoA. EC 4.2.1.17.