MeSH Browser

MeSH Heading: Dapsone
Tree Number(s): D02.886.590.263
Unique ID: D003622
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003622
Scope Note: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Entry Term(s): 4,4'-Diaminophenyl Sulfone; Avlosulfone; DADPS; Dapsoderm-X; Dapson-Fatol; Diaminodiphenylsulfone; Diaphenylsulfone; Disulone; Sulfona; Sulfonyldianiline
Pharm Action: Anti-Infective Agents
Antimalarials
Folic Acid Antagonists
Leprostatic Agents
Related Numbers: 80-08-0
NLM Classification #: QV 259
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0005661
Related Numbers: 80-08-0
Scope Note: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Terms: Dapsone Preferred Term
Term UI T010539
Date01/01/1999
LexicalTag NON
ThesaurusID; 4,4'-Diaminophenyl Sulfone
Term UI T010536
Date03/05/1981
LexicalTag NON
ThesaurusID UNK (19XX); DADPS
Term UI T010538
Date01/08/1981
LexicalTag ABB
ThesaurusID UNK (19XX); Diaminodiphenylsulfone
Term UI T010540
Date03/29/1974
LexicalTag NON
ThesaurusID UNK (19XX); Diaphenylsulfone
Term UI T010541
Date06/03/1982
LexicalTag NON
ThesaurusID; Sulfonyldianiline
Term UI T010543
Date03/29/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Dapsone MeSH Descriptor Data 2025