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Etoposide MeSH Descriptor Data 2023


MeSH Heading
Etoposide
Tree Number(s)
D02.455.426.559.847.638.960.675.250
D04.615.638.960.675.250
D09.408.348.275
Unique ID
D005047
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D005047
Scope Note
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Entry Term(s)
Celltop
Demethyl Epipodophyllotoxin Ethylidine Glucoside
Eposide
Eposin
Eto-GRY
Etomedac
Etopos
Etoposide Pierre Fabre
Etoposide Teva
Etoposide, (5S)-Isomer
Etoposide, (5a alpha)-Isomer
Etoposide, (5a alpha,9 alpha)-Isomer
Etoposide, alpha-D-Glucopyranosyl Isomer
Etoposido Ferrer Farma
Exitop
Lastet
NSC-141540
Onkoposid
Riboposid
Toposar
VP 16-213
VP-16
Vepesid
Vépéside-Sandoz
Pharm Action
Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors
Registry Number
6PLQ3CP4P3
Related Numbers
100007-53-2
33419-42-0
89301-95-1
96554-38-0
96554-41-5
CAS Type 1 Name
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
NLM Classification #
QV 269
Previous Indexing
Glucosides (1975)
Glycosides (1973-1974)
Podophyllotoxin (1973-1974)/analogs & derivatives (1975)
Public MeSH Note
87; was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Online Note
use ETOPOSIDE to search VP 16-213 1976-80
History Note
87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Date Established
1987/01/01
Date of Entry
1975/07/25
Revision Date
2018/03/01
Etoposide Preferred
Eto-GRY Narrower
Etoposide, (5a alpha,9 alpha)-Isomer Narrower
Etoposide, (5S)-Isomer Narrower
Etoposide, alpha-D-Glucopyranosyl Isomer Narrower
Etoposido Ferrer Farma Narrower
Exitop Narrower
Lastet Narrower
NSC-141540 Narrower
Onkoposid Narrower
Riboposid Narrower
Toposar Narrower
Vepesid Narrower
VP 16-213 Narrower
VP-16 Narrower
Vépéside-Sandoz Narrower
Celltop Narrower
Etopos Narrower
Etomedac Narrower
Eposin Narrower
Etoposide, (5a alpha)-Isomer Narrower
Etoposide Pierre Fabre Narrower
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