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Teniposide MeSH Descriptor Data 2023


MeSH Heading
Teniposide
Tree Number(s)
D09.408.348.800
Unique ID
D013713
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013713
Scope Note
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Entry Term(s)
Demethyl Epipodophyllotoxin Thenylidine Glucoside
NSC-122819
Teniposide, (5a alpha,9 alpha(S*))-Isomer
VM-26
Vumon
Pharm Action
Antineoplastic Agents
Topoisomerase II Inhibitors
Registry Number
957E6438QA
Related Numbers
29767-20-2
53956-10-8
89301-94-0
CAS Type 1 Name
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Previous Indexing
Glucosides (1975)
Glycosides (1973-1974)
Podophyllotoxin (1973-1974)
Public MeSH Note
91; was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80
Online Note
use TENIPOSIDE to search VM 26 1976-80
History Note
91(81); was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80
Date Established
1991/01/01
Date of Entry
1975/07/25
Revision Date
2016/07/01
Teniposide Preferred
Vumon Narrower
VM-26 Narrower
Teniposide, (5a alpha,9 alpha(S*))-Isomer Related
NSC-122819 Narrower
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