MeSH Browser

MeSH Heading: Guanethidine
Tree Number(s): D02.078.370.460
Unique ID: D006145
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006145
Scope Note: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Entry Term(s): ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine; Guanethidine Monosulfate; Guanethidine Sulfate; Guanethidine Sulfate (1:1); Guanethidine Sulfate (1:2); Guanethidine Sulfate (2:1); Guanethidine Sulfate (2:1), 14C-Labeled; Ismelin; Isobarin; Octadine; Oktadin
Pharm Action: Antihypertensive Agents
Sympatholytics
Adrenergic Agents
Registry Number: ZTI6C33Q2Q
Related Numbers: 14920-15-1; 55-65-2; 5UBY8Y002G; 60-02-6; 645-43-2; 87862-38-2; 8AQ60474G9
CAS Type 1 Name: Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0009675
Registry Number: ZTI6C33Q2Q
Related Numbers: 14920-15-1; 55-65-2; 5UBY8Y002G; 60-02-6; 645-43-2; 87862-38-2; 8AQ60474G9
Scope Note: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Terms: Guanethidine Preferred Term
Term UI T018643
Date01/01/1999
LexicalTag NON
ThesaurusID; Oktadin
Term UI T018644
Date10/11/1988
LexicalTag NON
ThesaurusID UNK (19XX); ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
Term UI T018645
Date03/22/1994
LexicalTag NON
ThesaurusID NLM (1995); Octadine
Term UI T018646
Date10/11/1988
LexicalTag NON
ThesaurusID UNK (19XX)

Guanethidine MeSH Descriptor Data 2023