MeSH Browser

MeSH Heading: Gabexate
Tree Number(s): D02.078.370.380
Unique ID: D016670
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016670
Scope Note: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Entry Term(s): Foy; Gabexate Mesilate; Gabexate Mesylate; Gabexate Methanesulfonate; Gabexate Monomethanesulfonate; Gabexate Monomethanesulfonate, 14C-Labeled Cpd
Pharm Action: Anticoagulants
Serine Proteinase Inhibitors
Related Numbers: 102391-46-8; 39492-01-8; 56974-48-2; 56974-61-9; E3Q07L0649
CAS Type 1 Name: Benzoic acid, 4-((6-((aminoiminomethyl)amino)-1-oxohexyl)oxy)-, ethyl ester
Previous Indexing: Anticoagulants (1966-1991); Guanidines (1966-1991); Protease Inhibitors (1979-1989); Serine Proteinase Inhibitors (1990-1991)
Public MeSH Note: 92; GABEXATE was indexed under GUANIDINES 1976-91
Online Note: use GABEXATE (NM) to search GABEXATE 1979-91
History Note: 92; was GABEXATE (NM) 1976-91
Date Established: 1992/01/01
Date of Entry: 1991/01/25
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Gabexate MeSH Descriptor Data 2025