MeSH Browser

MeSH Heading: Heavy Chain Disease
Tree Number(s): C15.378.147.780.490; C15.604.515.435; C20.683.780.490
Unique ID: D006362
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006362
Annotation: specify the immunoglobulin fragment coord NIM, as gamma chain dis = HEAVY CHAIN DISEASE (IM) + IMMUNOGLOBULIN GAMMA-CHAINS (NIM); ALPHA-CHAIN DISEASE see IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEASE is available
Scope Note: A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
Entry Version: HEAVY CHAIN DIS
Entry Term(s): Franklin Disease; Franklin's Disease; gamma-Chain Disease; mu-Chain Disease
See Also: Immunoglobulin Heavy Chains
Public MeSH Note: 66
History Note: 66(64)
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/07/01

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Heavy Chain Disease MeSH Descriptor Data 2025