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Immunoglobulin J-Chains MeSH Descriptor Data 2023


MeSH Heading
Immunoglobulin J-Chains
Tree Number(s)
D12.776.124.486.485.705.625
D12.776.124.790.651.705.625
D12.776.377.715.548.705.625
Unique ID
D007144
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007144
Scope Note
A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.
Entry Version
IG J CHAINS
Entry Term(s)
Ig J Chains
Ig J-Peptide
Immunoglobulin J Polypeptide
Immunoglobulin J-Peptide
J-Chains, Immunoglobulin
Pharm Action
Immunologic Factors
Registry Number
0
See Also
Immunoglobulin A
Immunoglobulin M
Public MeSH Note
2006; see IMMUNOGLOBULINS, J-CHAIN 1992-2005, see IMMUNOGLOBULINS, J CHAIN 1974-1991
History Note
2006 (1974)
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2019/07/02
Immunoglobulin J-Chains Preferred
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