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restrict to chemical changes of exogenous substances; IM general only; coordinate NIM with specific drug /pharmacokin (IM) or /metab
Scope Note
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
Entry Term(s)
Detoxication, Drug, Metabolic
Detoxification, Drug, Metabolic
Drug Detoxication, Metabolic
Metabolic Detoxication, Drug
Metabolic Detoxification, Drug
Metabolic Drug Inactivation
NLM Classification #
QV 38.5
Public MeSH Note
2015; see METABOLIC DETOXICATION, DRUG 1980-2014; see BIOTRANSFORMATION 1970-1979
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.