NLM Logo

Metabolic Detoxication, Phase I MeSH Descriptor Data 2022


MeSH Heading
Metabolic Detoxication, Phase I
Tree Number(s)
G03.171.450.500
G03.787.225.450.500
G07.690.725.225.450.500
Unique ID
D050216
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050216
Scope Note
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Entry Version
METAB DETOX PHASE I
Entry Term(s)
Metabolic Detoxication, Oxidative
Metabolic Detoxification, Phase I
Phase I Detoxification
See Also
Drug Interactions
Public MeSH Note
2006
History Note
2006
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2016/06/30
Metabolic Detoxication, Phase I Preferred
page delivered in 0.168s