MeSH Browser

MeSH Heading: Myosin-Light-Chain Kinase
Tree Number(s): D08.811.913.696.620.682.700.125.500; D12.776.476.563.125.500
Unique ID: D009219
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009219
Scope Note: An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
Entry Version: MLCK
Entry Term(s): Myosin Kinase; Myosin LCK; Myosin Regulatory Light-Chain Kinase
Registry Numbers: EC 2.7.11.18
CAS Type 1 Name: ATP:myosin-light-chain O-phosphotransferase
Previous Indexing: Phosphotransferases, ATP (1966-1972); Protein Kinases (1973-1986)
Public MeSH Note: 87
History Note: 87
Date Established: 1987/01/01
Date of Entry: 1986/06/16
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0014367
Registry Numbers: EC 2.7.11.18
Scope Note: An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
Terms: Myosin-Light-Chain Kinase Preferred Term
Term UI T027489
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1987); Myosin LCK
Term UI T027487
Date06/16/1986
LexicalTag NON
ThesaurusID UNK (19XX); Myosin Kinase
Term UI T027486
Date06/16/1986
LexicalTag NON
ThesaurusID UNK (19XX); Myosin Regulatory Light-Chain Kinase
Term UI T027488
Date08/10/1987
LexicalTag NON
ThesaurusID UNK (19XX)

Myosin-Light-Chain Kinase MeSH Descriptor Data 2024