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Nitric Oxide MeSH Descriptor Data 2023


MeSH Heading
Nitric Oxide
Tree Number(s)
D01.339.387
D01.625.550.500
D01.625.700.500
D01.650.550.587.600
Unique ID
D009569
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D009569
Scope Note
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Entry Term(s)
Endogenous Nitrate Vasodilator
Mononitrogen Monoxide
Nitric Oxide, Endothelium-Derived
Nitrogen Monoxide
Pharm Action
Bronchodilator Agents
Free Radical Scavengers
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Gasotransmitters
Registry Number
31C4KY9ESH
Related Numbers
10102-43-9
CAS Type 1 Name
Nitrogen oxide (NO)
See Also
Endothelium-Dependent Relaxing Factors
Fractional Exhaled Nitric Oxide Testing
Nitric Oxide Donors
Public MeSH Note
1965
History Note
1965
Date Established
1965/01/01
Date of Entry
1999/01/01
Revision Date
2021/03/12
Nitric Oxide Preferred
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