MeSH Browser

MeSH Heading: Nitric Oxide
Tree Number(s): D01.339.409.500; D01.625.550.500; D01.625.700.500; D01.650.550.587.600; D02.389.508.500
Unique ID: D009569
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009569
Scope Note: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Entry Term(s): Endogenous Nitrate Vasodilator; Mononitrogen Monoxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide
Pharm Action: Bronchodilator Agents
Free Radical Scavengers
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Gasotransmitters
Related Numbers: 10102-43-9
CAS Type 1 Name: Nitrogen oxide (NO)
See Also: Endothelium-Dependent Relaxing Factors; Fractional Exhaled Nitric Oxide Testing; Nitric Oxide Donors
Public MeSH Note: 1965
History Note: 1965
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2023/02/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0014877
Related Numbers: 10102-43-9
Scope Note: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Terms: Nitric Oxide Preferred Term
Term UI T028507
Date01/01/1999
LexicalTag NON
ThesaurusID; Nitrogen Monoxide
Term UI T028508
Date05/19/1981
LexicalTag NON
ThesaurusID; Mononitrogen Monoxide
Term UI T028510
Date02/24/1998
LexicalTag NON
ThesaurusID NLM (1999); Endogenous Nitrate Vasodilator
Term UI T046281
Date01/31/1989
LexicalTag NON
ThesaurusID NLM (1990); Nitric Oxide, Endothelium-Derived
Term UI T046285
Date02/25/1993
LexicalTag NON
ThesaurusID NLM (1994)

Nitric Oxide MeSH Descriptor Data 2025