MeSH Browser

MeSH Heading: Peptide Chain Initiation, Translational
Tree Number(s): G02.111.660.871.650; G03.734.871.650
Unique ID: D010442
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D010442
Annotation: coordinate with specific peptide; for protein biosynthesis on the ribosome only; for non-ribosomal biosynthesis use PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT
Scope Note: A process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis.
Entry Term(s): Chain Initiation, Peptide, Translational; Protein Biosynthesis Initiation; Protein Chain Initiation, Translational; Protein Translation Initiation; Translation Initiation, Genetic; Translation Initiation, Protein; Translational Initiation, Protein; Translational Peptide Chain Initiation
Previous Indexing: Peptides/biosynthesis (1966-1970)
See Also: Codon, Initiator; Peptide Initiation Factors; Protein Synthesis Inhibitors
Public MeSH Note: 2005; see PEPTIDE CHAIN INITIATION 1973-2004
History Note: 73(71)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Peptide Chain Initiation, Translational MeSH Descriptor Data 2025