MeSH Browser

MeSH Heading: Pyrimidine Dimers
Tree Number(s): D03.383.742.686.600; D13.695.578.424.600; D13.695.740.600; G05.200.615
Unique ID: D011740
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011740
Scope Note: Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.
Entry Term(s): Cyclobutane Pyrimidine Dimer; Cyclobutane-Pyrimidine Dimer; Cyclobutane-Pyrimidine Dimers; Cytosine-Thymine Dimer; Cytosine-Thymine Dimers; Pyrimidine Dimer; Thymine Dimer; Thymine Dimers; Thymine-Cyclobutane Dimer; Thymine-Thymine Cyclobutane Dimer
Previous Indexing: Pyrimidine Nucleotides (1974-1976); Thymine Nucleotides (1972-1976)
See Also: DNA Damage
Public MeSH Note: 77
History Note: 77
Date Established: 1977/01/01
Date of Entry: 1976/04/16
Revision Date: 2023/05/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0018256
Scope Note: Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.
Terms: Pyrimidine Dimers Preferred Term
Term UI T034713
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Cyclobutane Pyrimidine Dimer
Term UI T000997569
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Cyclobutane-Pyrimidine Dimers
Term UI T034712
Date02/03/1982
LexicalTag NON
ThesaurusID UNK (19XX); Pyrimidine Dimer
Term UI T000997570
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Cyclobutane-Pyrimidine Dimer
Term UI T000997571
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021)

Concept UI: M0018257
Terms: Thymine-Cyclobutane Dimer Preferred Term
Term UI T034714
Date01/03/1985
LexicalTag NON
ThesaurusID UNK (19XX); Thymine Dimers
Term UI T034715
Date04/14/1976
LexicalTag NON
ThesaurusID UNK (19XX); Thymine-Thymine Cyclobutane Dimer
Term UI T034716
Date11/02/1988
LexicalTag NON
ThesaurusID UNK (19XX); Thymine Dimer
Term UI T000997573
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021)

Pyrimidine Dimers MeSH Descriptor Data 2025