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Trimethoprim MeSH Descriptor Data 2023


MeSH Heading
Trimethoprim
Tree Number(s)
D03.383.742.906
Unique ID
D014295
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D014295
Annotation
consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria
Scope Note
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Entry Term(s)
Proloprim
Trimpex
Pharm Action
Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors
Registry Number
AN164J8Y0X
Related Numbers
738-70-5
CAS Type 1 Name
2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-
NLM Classification #
QV 256
Previous Indexing
Anti-Infective Agents (1966-1971)
Folic Acid Antagonists (1966-1971)
Pyrimidines (1966-1971)
See Also
Trimethoprim Resistance
Public MeSH Note
1974
History Note
1974 (1972)
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2018/05/21
Trimethoprim Preferred
Trimpex Narrower
Proloprim Narrower
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