MeSH Browser

MeSH Heading: Trimethoprim
Tree Number(s): D03.383.742.906
Unique ID: D014295
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014295
Annotation: consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria
Scope Note: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Entry Term(s): Proloprim; Trimpex
Pharm Action: Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors
Related Numbers: 738-70-5
CAS Type 1 Name: 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-
NLM Classification #: QV 256
Previous Indexing: Anti-Infective Agents (1966-1971); Folic Acid Antagonists (1966-1971); Pyrimidines (1966-1971)
See Also: Trimethoprim Resistance
Public MeSH Note: 1974
History Note: 1974 (1972)
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Trimethoprim MeSH Descriptor Data 2025