MeSH Browser

MeSH Heading: Imatinib Mesylate
Tree Number(s): D02.065.277.456; D02.241.223.100.100.435; D02.455.426.559.389.127.085.465; D03.383.606.405; D03.383.742.349
Unique ID: D000068877
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000068877
Scope Note: A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.
Entry Term(s): Alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide; CGP 57148; CGP-57148; CGP57148B; Gleevec; Glivec; Imatinib; Imatinib Methanesulfonate; ST 1571; ST1571; STI 571; STI-571; STI571
Pharm Action: Antineoplastic Agents
Protein Kinase Inhibitors
Registry Number: 8A1O1M485B
Related Numbers: 220127-57-1; BKJ8M8G5HI
Public MeSH Note: 2016; IMATINIB MESYLATE was indexed under BENZAMIDES, PIPERAZINES, and PYRIMIDINES 1996-2015
History Note: 2016 (1996)
Date Established: 2016/01/01
Date of Entry: 2015/07/09
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Amides [D02.065]
  - Benzamides [D02.065.277]

Organic Chemicals [D02]
- Carboxylic Acids [D02.241]
  - Acids, Carbocyclic [D02.241.223]
    - Benzoates [D02.241.223.100]
      - Benzamides [D02.241.223.100.100]
        
        Acecainide [D02.241.223.100.100.033]
        
        Aminohippuric Acids [D02.241.223.100.100.100]
        
        Amisulpride [D02.241.223.100.100.110]
        
        Axitinib [D02.241.223.100.100.115]
        
        Bezafibrate [D02.241.223.100.100.120]
        
        Cisapride [D02.241.223.100.100.135]
        
        DEET [D02.241.223.100.100.230]
        
        Dinitolmide [D02.241.223.100.100.240]
        
        Hippurates [D02.241.223.100.100.400]
        
        Imatinib Mesylate [D02.241.223.100.100.435]
        
        Indoramin [D02.241.223.100.100.470]
        
        Metoclopramide [D02.241.223.100.100.510]
        
        Moclobemide [D02.241.223.100.100.600]
        
        Procainamide [D02.241.223.100.100.650]
        
        Procarbazine [D02.241.223.100.100.655]
        
        Raclopride [D02.241.223.100.100.761]
        
        Remoxipride [D02.241.223.100.100.796]
        
        Sulpiride [D02.241.223.100.100.866]
        
        Tiapride Hydrochloride [D02.241.223.100.100.933]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Aromatic [D02.455.426.559]
      - Benzene Derivatives [D02.455.426.559.389]
        
        Benzoates [D02.455.426.559.389.127]
        
        Benzamides [D02.455.426.559.389.127.085]
        
        Acecainide [D02.455.426.559.389.127.085.033]
        
        Aminohippuric Acids [D02.455.426.559.389.127.085.067]
        
        Amisulpride [D02.455.426.559.389.127.085.084]
        
        Axitinib [D02.455.426.559.389.127.085.093]
        
        Bezafibrate [D02.455.426.559.389.127.085.101]
        
        Cisapride [D02.455.426.559.389.127.085.135]
        
        DEET [D02.455.426.559.389.127.085.230]
        
        Dinitolmide [D02.455.426.559.389.127.085.240]
        
        Hippurates [D02.455.426.559.389.127.085.460]
        
        Imatinib Mesylate [D02.455.426.559.389.127.085.465]
        
        Indoramin [D02.455.426.559.389.127.085.470]
        
        Metoclopramide [D02.455.426.559.389.127.085.510]
        
        Moclobemide [D02.455.426.559.389.127.085.600]
        
        Procainamide [D02.455.426.559.389.127.085.650]
        
        Procarbazine [D02.455.426.559.389.127.085.655]
        
        Raclopride [D02.455.426.559.389.127.085.761]
        
        Remoxipride [D02.455.426.559.389.127.085.796]
        
        Sulpiride [D02.455.426.559.389.127.085.866]
        
        Tiapride Hydrochloride [D02.455.426.559.389.127.085.933]

Heterocyclic Compounds [D03]
- Heterocyclic Compounds, 1-Ring [D03.383]
  - Piperazines [D03.383.606]

Heterocyclic Compounds [D03]
- Heterocyclic Compounds, 1-Ring [D03.383]
  - Pyrimidines [D03.383.742]

Imatinib Mesylate Preferred

STI571 Narrower

Gleevec Narrower

ST 1571 Narrower

CGP 57148 Narrower

Imatinib Broader

Imatinib Mesylate MeSH Descriptor Data 2023