MeSH Browser

MeSH Heading: Bosentan
Tree Number(s): D02.065.884.135; D02.886.590.700.143; D03.383.742.060
Unique ID: D000077300
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077300
Scope Note: A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS.
Entry Term(s): 4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide; Bosentan Anhydrous; Bosentan Monohydrate; Ro 47-0203; Ro-47-0203; Tracleer
Pharm Action: Antihypertensive Agents
Endothelin Receptor Antagonists
Registry Number: Q326023R30
Related Numbers: 147536-97-8; XUL93R30K2
CAS Type 1 Name: Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)-
Public MeSH Note: 2019; BOSENTAN was indexed under SULFONAMIDES 1995-2018; and under RECEPTORS, ENDOTHELIN/antagonists 1994
History Note: 2019 (1994)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Bosentan MeSH Descriptor Data 2023