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Bosentan
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Bosentan
Tree Number(s)
D02.065.884.060.005
D02.455.426.559.389.085.005
D02.886.590.700.090.005
D02.886.590.700.143
D03.383.742.060
Unique ID
D000077300
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077300
Scope Note
A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage
PULMONARY HYPERTENSION
and
SYSTEMIC SCLEROSIS
.
Entry Term(s)
4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
Bosentan Anhydrous
Bosentan Monohydrate
Ro 47-0203
Ro-47-0203
Tracleer
Pharm Action
Antihypertensive Agents
Endothelin Receptor Antagonists
Related Numbers
147536-97-8
XUL93R30K2
CAS Type 1 Name
Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)-
Public MeSH Note
2019; BOSENTAN was indexed under SULFONAMIDES 1995-2018; and under RECEPTORS, ENDOTHELIN/antagonists 1994
History Note
2019 (1994)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2023/06/08
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analogs & derivatives (AA)
analysis (AN)
antagonists & inhibitors (AI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
economics (EC)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
urine (UR)
Organic Chemicals [D02]
Amides [D02.065]
Sulfonamides [D02.065.884]
Benzenesulfonamides [D02.065.884.060]
Acetohexamide [D02.065.884.060.003]
Bosentan [D02.065.884.060.005]
Carbutamide [D02.065.884.060.010]
Celecoxib [D02.065.884.060.020]
Chlorpropamide [D02.065.884.060.040]
Chlorthalidone [D02.065.884.060.050]
Gliclazide [D02.065.884.060.100]
Mafenide [D02.065.884.060.150]
Sulfachlorpyridazine [D02.065.884.060.160]
Sulfadiazine [D02.065.884.060.170]
Sulfadimethoxine [D02.065.884.060.180]
Sulfadoxine [D02.065.884.060.190]
Sulfaguanidine [D02.065.884.060.200]
Sulfalene [D02.065.884.060.210]
Sulfamerazine [D02.065.884.060.220]
Sulfameter [D02.065.884.060.230]
Sulfamethazine [D02.065.884.060.240]
Sulfamethizole [D02.065.884.060.250]
Sulfamethoxazole [D02.065.884.060.300]
Sulfamethoxypyridazine [D02.065.884.060.325]
Sulfamonomethoxine [D02.065.884.060.338]
Sulfamoxole [D02.065.884.060.344]
Sulfanilamide [D02.065.884.060.350]
Sulfaphenazole [D02.065.884.060.400]
Sulfapyridine [D02.065.884.060.450]
Sulfaquinoxaline [D02.065.884.060.500]
Sulfathiazole [D02.065.884.060.550]
Sulfisomidine [D02.065.884.060.600]
Sulfisoxazole [D02.065.884.060.650]
Tamsulosin [D02.065.884.060.700]
Tolazamide [D02.065.884.060.740]
Tolbutamide [D02.065.884.060.745]
Tosyllysine Chloromethyl Ketone [D02.065.884.060.872]
Tosylphenylalanyl Chloromethyl Ketone [D02.065.884.060.936]
Organic Chemicals [D02]
Hydrocarbons [D02.455]
Hydrocarbons, Cyclic [D02.455.426]
Hydrocarbons, Aromatic [D02.455.426.559]
Benzene Derivatives [D02.455.426.559.389]
Benzenesulfonamides [D02.455.426.559.389.085]
Acetohexamide [D02.455.426.559.389.085.003]
Bosentan [D02.455.426.559.389.085.005]
Carbutamide [D02.455.426.559.389.085.010]
Celecoxib [D02.455.426.559.389.085.020]
Chlorpropamide [D02.455.426.559.389.085.040]
Chlorthalidone [D02.455.426.559.389.085.050]
Gliclazide [D02.455.426.559.389.085.100]
Mafenide [D02.455.426.559.389.085.150]
Sulfachlorpyridazine [D02.455.426.559.389.085.160]
Sulfadiazine [D02.455.426.559.389.085.170]
Sulfadimethoxine [D02.455.426.559.389.085.180]
Sulfadoxine [D02.455.426.559.389.085.190]
Sulfaguanidine [D02.455.426.559.389.085.200]
Sulfalene [D02.455.426.559.389.085.210]
Sulfamerazine [D02.455.426.559.389.085.220]
Sulfameter [D02.455.426.559.389.085.230]
Sulfamethazine [D02.455.426.559.389.085.240]
Sulfamethizole [D02.455.426.559.389.085.250]
Sulfamethoxazole [D02.455.426.559.389.085.300]
Sulfamethoxypyridazine [D02.455.426.559.389.085.325]
Sulfamonomethoxine [D02.455.426.559.389.085.338]
Sulfamoxole [D02.455.426.559.389.085.344]
Sulfanilamide [D02.455.426.559.389.085.350]
Sulfaphenazole [D02.455.426.559.389.085.400]
Sulfapyridine [D02.455.426.559.389.085.450]
Sulfaquinoxaline [D02.455.426.559.389.085.500]
Sulfathiazole [D02.455.426.559.389.085.550]
Sulfisomidine [D02.455.426.559.389.085.600]
Sulfisoxazole [D02.455.426.559.389.085.650]
Tamsulosin [D02.455.426.559.389.085.700]
Tolazamide [D02.455.426.559.389.085.740]
Tolbutamide [D02.455.426.559.389.085.745]
Tosyllysine Chloromethyl Ketone [D02.455.426.559.389.085.872]
Tosylphenylalanyl Chloromethyl Ketone [D02.455.426.559.389.085.936]
Organic Chemicals [D02]
Sulfur Compounds [D02.886]
Sulfones [D02.886.590]
Sulfonamides [D02.886.590.700]
Benzenesulfonamides [D02.886.590.700.090]
Acetohexamide [D02.886.590.700.090.003]
Bosentan [D02.886.590.700.090.005]
Carbutamide [D02.886.590.700.090.010]
Celecoxib [D02.886.590.700.090.020]
Chlorpropamide [D02.886.590.700.090.040]
Chlorthalidone [D02.886.590.700.090.050]
Gliclazide [D02.886.590.700.090.100]
Mafenide [D02.886.590.700.090.150]
Sulfachlorpyridazine [D02.886.590.700.090.160]
Sulfadiazine [D02.886.590.700.090.170]
Sulfadimethoxine [D02.886.590.700.090.180]
Sulfadoxine [D02.886.590.700.090.190]
Sulfaguanidine [D02.886.590.700.090.200]
Sulfalene [D02.886.590.700.090.210]
Sulfamerazine [D02.886.590.700.090.220]
Sulfameter [D02.886.590.700.090.230]
Sulfamethazine [D02.886.590.700.090.240]
Sulfamethizole [D02.886.590.700.090.250]
Sulfamethoxazole [D02.886.590.700.090.300]
Sulfamethoxypyridazine [D02.886.590.700.090.325]
Sulfamonomethoxine [D02.886.590.700.090.338]
Sulfamoxole [D02.886.590.700.090.344]
Sulfanilamide [D02.886.590.700.090.350]
Sulfaphenazole [D02.886.590.700.090.400]
Sulfapyridine [D02.886.590.700.090.450]
Sulfaquinoxaline [D02.886.590.700.090.500]
Sulfathiazole [D02.886.590.700.090.550]
Sulfisomidine [D02.886.590.700.090.600]
Sulfisoxazole [D02.886.590.700.090.650]
Tamsulosin [D02.886.590.700.090.700]
Tolazamide [D02.886.590.700.090.740]
Tolbutamide [D02.886.590.700.090.745]
Tosyllysine Chloromethyl Ketone [D02.886.590.700.090.872]
Tosylphenylalanyl Chloromethyl Ketone [D02.886.590.700.090.936]
Organic Chemicals [D02]
Sulfur Compounds [D02.886]
Sulfones [D02.886.590]
Sulfonamides [D02.886.590.700]
Benzenesulfonamides [D02.886.590.700.090]
Benzolamide [D02.886.590.700.120]
Benzothiadiazines [D02.886.590.700.135]
Bosentan [D02.886.590.700.143]
Bumetanide [D02.886.590.700.150]
Celecoxib [D02.886.590.700.247]
Chlorthalidone [D02.886.590.700.365]
Clopamide [D02.886.590.700.390]
Darunavir [D02.886.590.700.400]
Dichlorphenamide [D02.886.590.700.410]
Ethoxzolamide [D02.886.590.700.420]
Indapamide [D02.886.590.700.540]
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine [D02.886.590.700.545]
Mafenide [D02.886.590.700.570]
Mefruside [D02.886.590.700.575]
Metolazone [D02.886.590.700.600]
Probenecid [D02.886.590.700.625]
Rosuvastatin Calcium [D02.886.590.700.650]
Sildenafil Citrate [D02.886.590.700.675]
Simeprevir [D02.886.590.700.700]
Sulfanilamides [D02.886.590.700.725]
Sulfasalazine [D02.886.590.700.730]
Sumatriptan [D02.886.590.700.750]
Tamsulosin [D02.886.590.700.863]
Torsemide [D02.886.590.700.891]
Vemurafenib [D02.886.590.700.919]
Xipamide [D02.886.590.700.975]
Zonisamide [D02.886.590.700.987]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Bosentan [D03.383.742.060]
Buspirone [D03.383.742.120]
Dasatinib [D03.383.742.148]
Dipyridamole [D03.383.742.175]
Epirizole [D03.383.742.200]
Hexetidine [D03.383.742.279]
Imatinib Mesylate [D03.383.742.349]
Minoxidil [D03.383.742.418]
Mopidamol [D03.383.742.430]
Morantel [D03.383.742.440]
Nicarbazin [D03.383.742.470]
Oxypurinol [D03.383.742.550]
Paliperidone Palmitate [D03.383.742.592]
Pyrantel [D03.383.742.634]
Pyrimethamine [D03.383.742.675]
Pyrimidine Nucleosides [D03.383.742.680]
Pyrimidine Nucleotides [D03.383.742.686]
Pyrimidinones [D03.383.742.698]
Pyrithiamine [D03.383.742.715]
Rilpivirine [D03.383.742.755]
Rosuvastatin Calcium [D03.383.742.775]
Thiamine [D03.383.742.795]
Trapidil [D03.383.742.875]
Trimethoprim [D03.383.742.906]
Expand All
Collapse All
Bosentan
Preferred
Concept UI
M000640413
Related Numbers
147536-97-8
XUL93R30K2
Scope Note
A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage
PULMONARY HYPERTENSION
and
SYSTEMIC SCLEROSIS
.
Terms
Bosentan
Preferred Term
Term UI
T000938957
Date
01/11/2018
LexicalTag
NON
ThesaurusID
4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
Term UI
T000938959
Date
01/11/2018
LexicalTag
NON
ThesaurusID
NLM (1994)
Ro 47-0203
Narrower
Concept UI
M0228617
Terms
Ro 47-0203
Preferred Term
Term UI
T000940020
Date
02/02/2018
LexicalTag
LAB
ThesaurusID
NLM (1994)
Ro-47-0203
Term UI
T000940021
Date
02/02/2018
LexicalTag
LAB
ThesaurusID
NLM (1994)
Tracleer
Narrower
Concept UI
M0413789
Terms
Tracleer
Preferred Term
Term UI
T481180
Date
02/07/2002
LexicalTag
TRD
ThesaurusID
Bosentan Anhydrous
Narrower
Concept UI
M0585634
Terms
Bosentan Anhydrous
Preferred Term
Term UI
T000938960
Date
01/11/2018
LexicalTag
NON
ThesaurusID
Bosentan Monohydrate
Narrower
Concept UI
M000637175
Terms
Bosentan Monohydrate
Preferred Term
Term UI
T000938961
Date
01/11/2018
LexicalTag
NON
ThesaurusID
NLM (2004)
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