MeSH Browser

MeSH Heading: Simeprevir
Tree Number(s): D02.886.590.700.700; D03.633.300.819
Unique ID: D000069616
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000069616
Scope Note: Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS.
Entry Term(s): N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide; Olysio; TMC 435; TMC 435350; TMC-435; TMC-435350; TMC435; TMC435350
Pharm Action: Antiviral Agents
Protease Inhibitors
Public MeSH Note: 2016; SIMEPREVIR was indexed under SULFONAMIDES and HETEROCYCLIC COMPOUNDS, 3-RING 2008-2015
History Note: 2016 (2008)
Date Established: 2016/01/01
Date of Entry: 2015/07/10
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Simeprevir MeSH Descriptor Data 2025