MeSH Browser

MeSH Heading: Deoxyribonucleases, Type I Site-Specific
Tree Number(s): D08.811.150.280.250; D08.811.277.352.335.350.300.250; D08.811.277.352.355.325.300.250
Unique ID: D015253
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015253
Scope Note: Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.
Entry Version: DNASE SS I
Entry Term(s): DNA Restriction Enzymes, Type I; DNase, Site Specific, Type I; DNase, Site-Specific, Type I; Deoxyribonucleases, Type I, Site Specific; Deoxyribonucleases, Type I, Site-Specific; Restriction Endonucleases, Type I; Site-Specific DNase, Type I; Type I Restriction Enzymes; Type I Site Specific DNase; Type I Site Specific Deoxyribonucleases; Type I Site-Specific DNase; Type I Site-Specific Deoxyribonucleases
Registry Numbers: EC 3.1.21.3
Previous Indexing: DNA Restriction Enzymes (1978-1988)
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/05/17
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - DNA Restriction-Modification Enzymes [D08.811.150]
    - DNA Restriction Enzymes [D08.811.150.280]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Deoxyribonucleases [D08.811.277.352.335]
        
        Endodeoxyribonucleases [D08.811.277.352.335.350]
        
        DNA Restriction Enzymes [D08.811.277.352.335.350.300]
        
        Deoxyribonucleases, Type I Site-Specific [D08.811.277.352.335.350.300.250]
        
        Deoxyribonucleases, Type II Site-Specific [D08.811.277.352.335.350.300.260]
        
        Deoxyribonucleases, Type III Site-Specific [D08.811.277.352.335.350.300.270]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Endonucleases [D08.811.277.352.355]
        
        Endodeoxyribonucleases [D08.811.277.352.355.325]
        
        DNA Restriction Enzymes [D08.811.277.352.355.325.300]
        
        Deoxyribonucleases, Type I Site-Specific [D08.811.277.352.355.325.300.250]
        
        Deoxyribonucleases, Type II Site-Specific [D08.811.277.352.355.325.300.260]
        
        Deoxyribonucleases, Type III Site-Specific [D08.811.277.352.355.325.300.270]

Deoxyribonucleases, Type I Site-Specific Preferred

Concept UI: M0023491
Registry Numbers: EC 3.1.21.3
Scope Note: Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.
Terms: Deoxyribonucleases, Type I Site-Specific Preferred Term
Term UI T044766
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1989); Deoxyribonucleases, Type I, Site-Specific
Term UI T044763
Date04/05/1989
LexicalTag NON
ThesaurusID NLM (1990); Type I Site Specific Deoxyribonucleases
Term UI T044764
Date02/08/1989
LexicalTag NON
ThesaurusID NLM (1989); Type I Site-Specific Deoxyribonucleases
Term UI T044765
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); DNA Restriction Enzymes, Type I
Term UI T044767
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); DNase, Site Specific, Type I
Term UI T044768
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); Site-Specific DNase, Type I
Term UI T044769
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); Type I Site Specific DNase
Term UI T044770
Date02/08/1989
LexicalTag NON
ThesaurusID NLM (1989); Type I Site-Specific DNase
Term UI T044771
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); DNase, Site-Specific, Type I
Term UI T044772
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); Restriction Endonucleases, Type I
Term UI T044773
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); Deoxyribonucleases, Type I, Site Specific
Term UI T044762
Date12/05/1988
LexicalTag NON
ThesaurusID NLM (1989); Type I Restriction Enzymes
Term UI T044774
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX)

Deoxyribonucleases, Type I Site-Specific MeSH Descriptor Data 2024