MeSH Browser

MeSH Heading: Ophthalmoplegia, Chronic Progressive External
Tree Number(s): C05.651.460.700; C10.292.562.750.250; C10.597.622.447.511; C10.668.491.500.700; C11.590.472.250; C18.452.660.560.700; C23.550.291.500.688; C23.888.592.636.447.511
Unique ID: D017246
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017246
Annotation: chronic progressive external ophthalmoplegia with cardiomyopathy & retinitis pigmentosa = KEARNS-SAYRE SYNDROME
Scope Note: A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
Entry Term(s): CPEO; Chronic Progressive External Ophthalmoplegia; Graefe Disease; Graefe's Disease; Mitochondrial Ocular Myopathy; Ocular Muscular Dystrophy; Ocular Myopathy of Von Graefe-Fuchs; Ophthalmoplegia, Progressive External; Progressive External Ophthalmoplegia
Previous Indexing: DNA, Mitochondrial (1988-1992); Mitochondria, Muscle (1972-1992); Ophthalmoplegia (1966-1992)
Public MeSH Note: 93
History Note: 93
Date Established: 1993/01/01
Date of Entry: 1992/05/22
Revision Date: 2021/03/12

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]
  - Mitochondrial Myopathies [C05.651.460]
    - Mitochondrial Encephalomyopathies [C05.651.460.620]
    - Ophthalmoplegia, Chronic Progressive External [C05.651.460.700]
      - Kearns-Sayre Syndrome [C05.651.460.700.500]

Nervous System Diseases [C10]
- Cranial Nerve Diseases [C10.292]
  - Ocular Motility Disorders [C10.292.562]
    - Ophthalmoplegia [C10.292.562.750]

Nervous System Diseases [C10]
- Neurologic Manifestations [C10.597]
  - Paralysis [C10.597.622]
    - Ophthalmoplegia [C10.597.622.447]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Muscular Diseases [C10.668.491]
    - Mitochondrial Myopathies [C10.668.491.500]
      - Mitochondrial Encephalomyopathies [C10.668.491.500.500]
      - Ophthalmoplegia, Chronic Progressive External [C10.668.491.500.700]
        
        Kearns-Sayre Syndrome [C10.668.491.500.700.500]

Eye Diseases [C11]
- Ocular Motility Disorders [C11.590]
  - Ophthalmoplegia [C11.590.472]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Mitochondrial Diseases [C18.452.660]
    - Mitochondrial Myopathies [C18.452.660.560]
      - Mitochondrial Encephalomyopathies [C18.452.660.560.620]
      - Ophthalmoplegia, Chronic Progressive External [C18.452.660.560.700]
        
        Kearns-Sayre Syndrome [C18.452.660.560.700.500]

Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
  - Disease Attributes [C23.550.291]
    - Chronic Disease [C23.550.291.500]

Pathological Conditions, Signs and Symptoms [C23]
- Signs and Symptoms [C23.888]
  - Neurologic Manifestations [C23.888.592]
    - Paralysis [C23.888.592.636]
      - Ophthalmoplegia [C23.888.592.636.447]
        
        Ophthalmoplegia, Chronic Progressive External [C23.888.592.636.447.511]
        
        Kearns-Sayre Syndrome [C23.888.592.636.447.511.500]
        
        Ophthalmoplegic Migraine [C23.888.592.636.447.600]
        
        Supranuclear Palsy, Progressive [C23.888.592.636.447.690]

Ophthalmoplegia, Chronic Progressive External Preferred

Concept UI: M0026169
Scope Note: A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
Terms: Ophthalmoplegia, Chronic Progressive External Preferred Term
Term UI T051414
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1993); CPEO
Term UI T051413
Date12/16/1991
LexicalTag ABB
ThesaurusID NLM (1993); Graefe Disease
Term UI T370629
Date11/04/1999
LexicalTag EPO
ThesaurusID NLM (2000); Mitochondrial Ocular Myopathy
Term UI T370630
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000); Ocular Muscular Dystrophy
Term UI T370631
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000); Graefe's Disease
Term UI T370632
Date11/04/1999
LexicalTag EPO
ThesaurusID NLM (2000); Ocular Myopathy of Von Graefe-Fuchs
Term UI T370633
Date11/04/1999
LexicalTag EPO
ThesaurusID NLM (2000); Ophthalmoplegia, Progressive External
Term UI T370634
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000); Progressive External Ophthalmoplegia
Term UI T370635
Date11/04/1999
LexicalTag NON
ThesaurusID; Chronic Progressive External Ophthalmoplegia
Term UI T842328
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014)

Ophthalmoplegia, Chronic Progressive External MeSH Descriptor Data 2025