MeSH Browser

MeSH Heading: Fatigue Syndrome, Chronic
Tree Number(s): C05.651.310; C10.586.500.600; C10.668.364; C23.550.291.500.392
Unique ID: D015673
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015673
Annotation: a clinical entity: do not confuse with "chronic fatigue" (= FATIGUE + CHRONIC DISEASE (NIM))
Scope Note: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
Entry Term(s): Chronic Fatigue Disorder; Chronic Fatigue Syndrome; Chronic Fatigue and Immune Dysfunction Syndrome; Chronic Fatigue-Fibromyalgia Syndrome; Encephalomyelitis, Myalgic; Infectious Mononucleosis-Like Syndrome, Chronic; Myalgic Encephalomyelitis; Postviral Fatigue Syndrome; Royal Free Disease; Systemic Exertion Intolerance Disease
Previous Indexing: Encephalomyelitis (1966-1989); Fatigue (1977-1989); Muscular Diseases (1966-1989); Virus Diseases (1986-1989)
See Also: Fibromyalgia
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2023/04/05

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]

Nervous System Diseases [C10]
- Neuroinflammatory Diseases [C10.586]
  - Encephalomyelitis [C10.586.500]
    - Encephalomyelitis, Equine [C10.586.500.406]
    - Fatigue Syndrome, Chronic [C10.586.500.600]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]

Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
  - Disease Attributes [C23.550.291]
    - Chronic Disease [C23.550.291.500]

Fatigue Syndrome, Chronic Preferred

Concept UI: M0024027
Scope Note: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
Terms: Fatigue Syndrome, Chronic Preferred Term
Term UI T046399
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Chronic Fatigue-Fibromyalgia Syndrome
Term UI T368096
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000); Infectious Mononucleosis-Like Syndrome, Chronic
Term UI T046402
Date02/07/1989
LexicalTag NON
ThesaurusID NLM (1990); Royal Free Disease
Term UI T046403
Date02/07/1989
LexicalTag EPO
ThesaurusID NLM (1990); Chronic Fatigue and Immune Dysfunction Syndrome
Term UI T046404
Date07/14/1995
LexicalTag NON
ThesaurusID NLM (1997); Chronic Fatigue Disorder
Term UI T368095
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000); Systemic Exertion Intolerance Disease
Term UI T000906237
Date08/29/2016
LexicalTag NON
ThesaurusID NLM (2018); Myalgic Encephalomyelitis
Term UI T046396
Date02/10/1994
LexicalTag NON
ThesaurusID NLM (1995); Encephalomyelitis, Myalgic
Term UI T046397
Date02/07/1989
LexicalTag NON
ThesaurusID NLM (1990); Chronic Fatigue Syndrome
Term UI T046398
Date02/07/1989
LexicalTag NON
ThesaurusID NLM (1990); Postviral Fatigue Syndrome
Term UI T046401
Date02/07/1989
LexicalTag NON
ThesaurusID NLM (1990)

Fatigue Syndrome, Chronic MeSH Descriptor Data 2025