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Motor Neuron Disease MeSH Descriptor Data 2023


MeSH Heading
Motor Neuron Disease
Tree Number(s)
C10.574.562
C10.668.467
Unique ID
D016472
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016472
Annotation
general or unspecified; prefer specifics
Scope Note
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Entry Version
MOTOR NEURON DIS
Entry Term(s)
Anterior Horn Cell Disease
Familial Motor Neuron Disease
Lateral Sclerosis
Lower Motor Neuron Disease
Motor Neuron Disease, Familial
Motor Neuron Disease, Lower
Motor Neuron Disease, Secondary
Motor Neuron Disease, Upper
Motor System Disease
Primary Lateral Sclerosis
Secondary Motor Neuron Disease
Upper Motor Neuron Disease
NLM Classification #
WE 550
Previous Indexing
Motor Neurons (1966-1991)
Neuromuscular Diseases (1972-1991)
Public MeSH Note
92
History Note
92
Date Established
1992/01/01
Date of Entry
1991/06/21
Revision Date
2010/06/25
Motor Neuron Disease Preferred
Familial Motor Neuron Disease Narrower
Lateral Sclerosis Narrower
Motor Neuron Disease, Upper Narrower
Motor Neuron Disease, Secondary Narrower
Anterior Horn Cell Disease Narrower
Motor Neuron Disease, Lower Narrower
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