MeSH Browser

MeSH Heading: Stiff-Person Syndrome
Tree Number(s): C10.114.812; C10.228.854.790; C10.668.900; C20.111.258.850
Unique ID: D016750
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016750
Scope Note: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
Entry Term(s): Congenital Stiff-Man Syndrome; Congenital Stiff-Person Syndrome; Familial Hyperekplexia; Hereditary Hyperekplexia; Moersch-Woltmann Syndrome; Startle Syndrome; Stiff-Baby Syndrome; Stiff-Man Syndrome; Stiff-Trunk Syndrome; Stiffman Syndrome
Previous Indexing: Autoimmune Diseases (1988-1991); Central Nervous System Diseases (1986-1991); Fibromyalgia (1966-1976); Muscular Diseases (1966-1982); Neuromuscular Diseases (1972-1991)
Public MeSH Note: 2000; see STIFF-MAN SYNDROME 1992-1999
History Note: 2000(1992)
Date Established: 1992/01/01
Date of Entry: 1991/04/29
Revision Date: 2016/01/20

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Autoimmune Diseases of the Nervous System [C10.114]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Spinal Cord Diseases [C10.228.854]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]

Immune System Diseases [C20]
- Autoimmune Diseases [C20.111]
  - Autoimmune Diseases of the Nervous System [C20.111.258]

Stiff-Person Syndrome Preferred

Concept UI: M0025507
Scope Note: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
Terms: Stiff-Person Syndrome Preferred Term
Term UI T365296
Date11/03/1999
LexicalTag NON
ThesaurusID; Stiff-Man Syndrome
Term UI T050217
Date01/01/1999
LexicalTag NON
ThesaurusID; Stiffman Syndrome
Term UI T050218
Date01/14/1991
LexicalTag NON
ThesaurusID NLM (1992); Stiff-Trunk Syndrome
Term UI T811986
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Congenital Stiff-Man Syndrome
Term UI T841603
Date04/18/2013
LexicalTag NON
ThesaurusID NLM (2014); Congenital Stiff-Person Syndrome
Term UI T841604
Date04/18/2013
LexicalTag NON
ThesaurusID NLM (2014); Startle Syndrome
Term UI T841607
Date04/18/2013
LexicalTag NON
ThesaurusID NLM (2014); Moersch-Woltmann Syndrome
Term UI T050216
Date03/04/1991
LexicalTag EPO
ThesaurusID; Stiff-Baby Syndrome
Term UI T841608
Date04/18/2013
LexicalTag NON
ThesaurusID NLM (2014)

Familial Hyperekplexia Narrower

Hereditary Hyperekplexia Broader

Stiff-Person Syndrome MeSH Descriptor Data 2025