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Stiff-Person Syndrome MeSH Descriptor Data 2023


MeSH Heading
Stiff-Person Syndrome
Tree Number(s)
C10.114.812
C10.228.854.790
C10.668.900
C20.111.258.850
Unique ID
D016750
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016750
Scope Note
A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
Entry Term(s)
Congenital Stiff-Man Syndrome
Congenital Stiff-Person Syndrome
Familial Hyperekplexia
Hereditary Hyperekplexia
Moersch-Woltmann Syndrome
Startle Syndrome
Stiff-Baby Syndrome
Stiff-Man Syndrome
Stiff-Trunk Syndrome
Stiffman Syndrome
Previous Indexing
Autoimmune Diseases (1988-1991)
Central Nervous System Diseases (1986-1991)
Fibromyalgia (1966-1976)
Muscular Diseases (1966-1982)
Neuromuscular Diseases (1972-1991)
Public MeSH Note
2000; see STIFF-MAN SYNDROME 1992-1999
History Note
2000(1992)
Date Established
1992/01/01
Date of Entry
1991/04/29
Revision Date
2016/01/20
Stiff-Person Syndrome Preferred
Familial Hyperekplexia Narrower
Hereditary Hyperekplexia Broader
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