MeSH Browser

MeSH Heading: Synucleinopathies
Tree Number(s): C10.574.928; C18.452.845.650
Unique ID: D000080874
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000080874
Scope Note: Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
Entry Term(s): a-Synucleinopathies; alpha Synuclein Pathology; alpha-Synucleinopathies
Previous Indexing: alpha-Synuclein (1999-2019); Neurodegenerative Diseases (1998-2019)
See Also: alpha-Synuclein; Lewy Bodies
Public MeSH Note: 2020
History Note: 2020
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/05/17

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M000648557
Scope Note: Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
Terms: Synucleinopathies Preferred Term
Term UI T000955154
Date04/11/2019
LexicalTag NON
ThesaurusID NLM (2020); alpha-Synucleinopathies
Term UI T000955155
Date04/11/2019
LexicalTag NON
ThesaurusID NLM (2020); a-Synucleinopathies
Term UI T000955156
Date04/11/2019
LexicalTag NON
ThesaurusID NLM (2020); alpha Synuclein Pathology
Term UI T000955157
Date04/11/2019
LexicalTag NON
ThesaurusID NLM (2020)

Synucleinopathies MeSH Descriptor Data 2025