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TDP-43 Proteinopathies MeSH Descriptor Data 2023


MeSH Heading
TDP-43 Proteinopathies
Tree Number(s)
C10.574.950
C18.452.845.800
Unique ID
D057177
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D057177
Scope Note
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
Public MeSH Note
2010
History Note
2010
Date Established
2010/01/01
Date of Entry
2009/07/06
TDP-43 Proteinopathies Preferred
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