MeSH Browser

MeSH Heading: Isaacs Syndrome
Tree Number(s): C05.651.392; C10.668.829.425
Unique ID: D020386
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020386
Scope Note: A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
Entry Term(s): Acquired Neuromyotonia; Continuous Muscle Activity Syndrome; Gamstorp-Wohlfart Syndrome; Isaacs' Syndrome; Isaacs-Mertens Syndrome; Myokymia, Continuous; Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis; Neuromyotonia; Pseudomyotonia; Pseudomyotonia Syndrome of Isaacs; Quantal Squander; Syndrome of Continuous Muscle Activity
Previous Indexing: Fasciculation (1995-1999)
Public MeSH Note: 2000; for ISAACS' SYNDROME see FASCICULATION 1995-1999
History Note: 2000; for ISAACS' SYNDROME use FASCICULATION 1995-1999
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2019/05/17

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Peripheral Nervous System Diseases [C10.668.829]

Isaacs Syndrome Preferred

Concept UI: M0008237
Scope Note: A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
Terms: Isaacs Syndrome Preferred Term
Term UI T015973
Date09/16/1993
LexicalTag EPO
ThesaurusID NLM (1995); Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis
Term UI T812143
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Continuous Muscle Activity Syndrome
Term UI T369954
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Gamstorp-Wohlfart Syndrome
Term UI T369955
Date10/12/1999
LexicalTag EPO
ThesaurusID; Isaacs' Syndrome
Term UI T358686
Date10/12/1999
LexicalTag EPO
ThesaurusID NLM (2000); Isaacs-Mertens Syndrome
Term UI T015972
Date09/16/1993
LexicalTag EPO
ThesaurusID; Myokymia, Continuous
Term UI T369951
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Neuromyotonia
Term UI T369952
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Pseudomyotonia Syndrome of Isaacs
Term UI T369956
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Quantal Squander
Term UI T369957
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Syndrome of Continuous Muscle Activity
Term UI T369958
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

Acquired Neuromyotonia Narrower

Pseudomyotonia Related

Isaacs Syndrome MeSH Descriptor Data 2025