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Isaacs Syndrome MeSH Descriptor Data 2023

MeSH Heading
Isaacs Syndrome
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
Entry Term(s)
Acquired Neuromyotonia
Continuous Muscle Activity Syndrome
Gamstorp-Wohlfart Syndrome
Isaacs' Syndrome
Isaacs-Mertens Syndrome
Myokymia, Continuous
Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis
Pseudomyotonia Syndrome of Isaacs
Quantal Squander
Syndrome of Continuous Muscle Activity
Previous Indexing
Fasciculation (1995-1999)
Public MeSH Note
2000; for ISAACS' SYNDROME see FASCICULATION 1995-1999
History Note
2000; for ISAACS' SYNDROME use FASCICULATION 1995-1999
Date Established
Date of Entry
Revision Date
Isaacs Syndrome Preferred
Pseudomyotonia Related
Acquired Neuromyotonia Narrower
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