MeSH Browser

MeSH Heading: CD59 Antigens
Tree Number(s): D09.400.430.890.448.140; D12.776.395.550.448.140; D12.776.543.484.500.140; D12.776.543.550.418.140
Unique ID: D018957
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018957
Scope Note: Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
Entry Term(s): Antigens, CD59; CD59 Antigen; HRF20; Homologous Restriction Factor 20; MACIF; Membrane Attack Complex Inhibition Factor; Membrane Inhibitor of Reactive Lysis; Protectin
Pharm Action: Complement Inactivating Agents
Registry Numbers: 0
Previous Indexing: Antigens, CD (1990-1995); Antigens, Differentiation (1989-1991); Membrane Glycoproteins (1989-1995)
Public MeSH Note: 2018; see ANTIGENS, CD59 1996-2017 and CD59 ANTIGEN 1989-1995; CD59 ANTIGEN was indexed under ANTIGENS, CD 1990-1995; under MEMBRANE GLYCOPROTEINS 1989-1995; and under ANTIGENS, DIFFERENTIATION 1989-1991; MEMBRANE ATTACK COMPLEX INHIBITION FACTOR was indexed under PROTEINS 1992-1997 and under BLOOD PROTEINS 1990-1991; PROTECTIN was indexed under ION CHANNELS 1996-1999
History Note: 2018 (1990); for PROTECTIN use CATIONIC PROTEIN, URATE-CALCIUM OXALATE STONE 1996-1999
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - GPI-Linked Proteins [D09.400.430.890.448]
        
        Lipopolysaccharide Receptors [D09.400.430.890.448.100]
        
        CD24 Antigen [D09.400.430.890.448.120]
        
        CD55 Antigens [D09.400.430.890.448.130]
        
        CD59 Antigens [D09.400.430.890.448.140]
        
        Bone Marrow Stromal Antigen 2 [D09.400.430.890.448.150]
        
        Carbonic Anhydrase IV [D09.400.430.890.448.160]
        
        CD48 Antigen [D09.400.430.890.448.180]
        
        CD52 Antigen [D09.400.430.890.448.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D09.400.430.890.448.200]
        
        Contactins [D09.400.430.890.448.250]
        
        Ephrin-A1 [D09.400.430.890.448.300]
        
        Ephrin-A2 [D09.400.430.890.448.310]
        
        Ephrin-A3 [D09.400.430.890.448.320]
        
        Ephrin-A4 [D09.400.430.890.448.330]
        
        Ephrin-A5 [D09.400.430.890.448.340]
        
        Folate Receptors, GPI-Anchored [D09.400.430.890.448.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D09.400.430.890.448.400]
        
        Glypicans [D09.400.430.890.448.500]
        
        Mesothelin [D09.400.430.890.448.550]
        
        Prion Proteins [D09.400.430.890.448.600]
        
        Matrix Metalloproteinase 17 [D09.400.430.890.448.700]
        
        Nogo Receptors [D09.400.430.890.448.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D09.400.430.890.448.775]
        
        Receptors, Urokinase Plasminogen Activator [D09.400.430.890.448.813]
        
        Uromodulin [D09.400.430.890.448.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - GPI-Linked Proteins [D12.776.395.550.448]
        
        Lipopolysaccharide Receptors [D12.776.395.550.448.100]
        
        CD24 Antigen [D12.776.395.550.448.120]
        
        CD55 Antigens [D12.776.395.550.448.130]
        
        CD59 Antigens [D12.776.395.550.448.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.395.550.448.150]
        
        Carbonic Anhydrase IV [D12.776.395.550.448.160]
        
        CD48 Antigen [D12.776.395.550.448.180]
        
        CD52 Antigen [D12.776.395.550.448.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.395.550.448.200]
        
        Contactins [D12.776.395.550.448.250]
        
        Ephrin-A1 [D12.776.395.550.448.300]
        
        Ephrin-A2 [D12.776.395.550.448.310]
        
        Ephrin-A3 [D12.776.395.550.448.320]
        
        Ephrin-A4 [D12.776.395.550.448.330]
        
        Ephrin-A5 [D12.776.395.550.448.340]
        
        Folate Receptors, GPI-Anchored [D12.776.395.550.448.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.395.550.448.400]
        
        Glypicans [D12.776.395.550.448.500]
        
        Mesothelin [D12.776.395.550.448.550]
        
        Prion Proteins [D12.776.395.550.448.600]
        
        Matrix Metalloproteinase 17 [D12.776.395.550.448.700]
        
        Nogo Receptors [D12.776.395.550.448.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.395.550.448.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.395.550.448.813]
        
        Uromodulin [D12.776.395.550.448.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Lipid-Linked Proteins [D12.776.543.484]
      - GPI-Linked Proteins [D12.776.543.484.500]
        
        Lipopolysaccharide Receptors [D12.776.543.484.500.100]
        
        CD24 Antigen [D12.776.543.484.500.120]
        
        CD55 Antigens [D12.776.543.484.500.130]
        
        CD59 Antigens [D12.776.543.484.500.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.543.484.500.150]
        
        Carbonic Anhydrase IV [D12.776.543.484.500.160]
        
        CD48 Antigen [D12.776.543.484.500.180]
        
        CD52 Antigen [D12.776.543.484.500.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.484.500.200]
        
        Contactins [D12.776.543.484.500.250]
        
        Ephrin-A1 [D12.776.543.484.500.300]
        
        Ephrin-A2 [D12.776.543.484.500.310]
        
        Ephrin-A3 [D12.776.543.484.500.320]
        
        Ephrin-A4 [D12.776.543.484.500.330]
        
        Ephrin-A5 [D12.776.543.484.500.340]
        
        Folate Receptors, GPI-Anchored [D12.776.543.484.500.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.484.500.400]
        
        Glypicans [D12.776.543.484.500.550]
        
        Mesothelin [D12.776.543.484.500.588]
        
        Prion Proteins [D12.776.543.484.500.625]
        
        Matrix Metalloproteinase 17 [D12.776.543.484.500.700]
        
        Nogo Receptors [D12.776.543.484.500.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.543.484.500.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.543.484.500.813]
        
        Uromodulin [D12.776.543.484.500.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - GPI-Linked Proteins [D12.776.543.550.418]
        
        Lipopolysaccharide Receptors [D12.776.543.550.418.100]
        
        CD24 Antigen [D12.776.543.550.418.120]
        
        CD55 Antigens [D12.776.543.550.418.130]
        
        CD59 Antigens [D12.776.543.550.418.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.543.550.418.150]
        
        Carbonic Anhydrase IV [D12.776.543.550.418.160]
        
        CD48 Antigen [D12.776.543.550.418.180]
        
        CD52 Antigen [D12.776.543.550.418.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.550.418.200]
        
        Contactins [D12.776.543.550.418.250]
        
        Ephrin-A1 [D12.776.543.550.418.300]
        
        Ephrin-A2 [D12.776.543.550.418.310]
        
        Ephrin-A3 [D12.776.543.550.418.320]
        
        Ephrin-A4 [D12.776.543.550.418.330]
        
        Ephrin-A5 [D12.776.543.550.418.340]
        
        Folate Receptors, GPI-Anchored [D12.776.543.550.418.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.550.418.400]
        
        Glypicans [D12.776.543.550.418.500]
        
        Mesothelin [D12.776.543.550.418.550]
        
        Prion Proteins [D12.776.543.550.418.600]
        
        Matrix Metalloproteinase 17 [D12.776.543.550.418.700]
        
        Nogo Receptors [D12.776.543.550.418.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.543.550.418.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.543.550.418.813]
        
        Uromodulin [D12.776.543.550.418.850]

CD59 Antigens Preferred

Concept UI: M0028327
Registry Numbers: 0
Scope Note: Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
Terms: CD59 Antigens Preferred Term
Term UI T056513
Date11/23/1994
LexicalTag NON
ThesaurusID NLM (1996); Antigens, CD59
Term UI T056514
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1996); Membrane Attack Complex Inhibition Factor
Term UI T056515
Date12/16/1996
LexicalTag NON
ThesaurusID NLM (1998); HRF20
Term UI T056516
Date11/23/1994
LexicalTag NON
ThesaurusID NLM (1996); MACIF
Term UI T056517
Date12/16/1996
LexicalTag NON
ThesaurusID NLM (1998); Membrane Inhibitor of Reactive Lysis
Term UI T056518
Date11/23/1994
LexicalTag NON
ThesaurusID NLM (1996); Homologous Restriction Factor 20
Term UI T056519
Date11/23/1994
LexicalTag NON
ThesaurusID NLM (1996); CD59 Antigen
Term UI T056512
Date11/23/1994
LexicalTag NON
ThesaurusID NLM (1996); Protectin
Term UI T259265
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000)

CD59 Antigens MeSH Descriptor Data 2025