MeSH Browser

MeSH Heading: Glial Cell Line-Derived Neurotrophic Factor Receptors
Tree Number(s): D09.400.430.890.448.400; D12.776.395.550.448.400; D12.776.543.484.500.400; D12.776.543.550.418.400; D12.776.543.750.750.400.550.124
Unique ID: D051097
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051097
Scope Note: A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored cell surface receptors that are specific for GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS. They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein.
Entry Term(s): GDNF Family Receptor 1; GDNF Family Receptor 2; GDNF Family Receptor 3; GDNF Family Receptor 4; GDNF Family Receptor Alpha 1; GDNF Family Receptor Alpha 2; GDNF Family Receptor Alpha 3; GDNF Family Receptor Alpha 4; GDNF Receptors; GFRA1 Receptor; GFRA2 Receptor; GFRA3 Receptor; GFRA4 Receptor; Glial Derived Neurotrophic Factor Receptor 1; Glial Derived Neurotrophic Factor Receptor 2; Glial Derived Neurotrophic Factor Receptor 3; Glial Derived Neurotrophic Factor Receptor 4
Public MeSH Note: 2006; GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR RECEPTORS was indexed under PROTO-ONCOGENE PROTEINS & RECEPTOR PROTEIN-TYROSINE KINASES 1999-2005
History Note: 2006(1999)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - GPI-Linked Proteins [D09.400.430.890.448]
        
        Lipopolysaccharide Receptors [D09.400.430.890.448.100]
        
        CD24 Antigen [D09.400.430.890.448.120]
        
        CD55 Antigens [D09.400.430.890.448.130]
        
        CD59 Antigens [D09.400.430.890.448.140]
        
        Bone Marrow Stromal Antigen 2 [D09.400.430.890.448.150]
        
        Carbonic Anhydrase IV [D09.400.430.890.448.160]
        
        CD48 Antigen [D09.400.430.890.448.180]
        
        CD52 Antigen [D09.400.430.890.448.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D09.400.430.890.448.200]
        
        Contactins [D09.400.430.890.448.250]
        
        Ephrin-A1 [D09.400.430.890.448.300]
        
        Ephrin-A2 [D09.400.430.890.448.310]
        
        Ephrin-A3 [D09.400.430.890.448.320]
        
        Ephrin-A4 [D09.400.430.890.448.330]
        
        Ephrin-A5 [D09.400.430.890.448.340]
        
        Folate Receptors, GPI-Anchored [D09.400.430.890.448.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D09.400.430.890.448.400]
        
        Glypicans [D09.400.430.890.448.500]
        
        Mesothelin [D09.400.430.890.448.550]
        
        Prion Proteins [D09.400.430.890.448.600]
        
        Matrix Metalloproteinase 17 [D09.400.430.890.448.700]
        
        Nogo Receptors [D09.400.430.890.448.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D09.400.430.890.448.775]
        
        Receptors, Urokinase Plasminogen Activator [D09.400.430.890.448.813]
        
        Uromodulin [D09.400.430.890.448.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - GPI-Linked Proteins [D12.776.395.550.448]
        
        Lipopolysaccharide Receptors [D12.776.395.550.448.100]
        
        CD24 Antigen [D12.776.395.550.448.120]
        
        CD55 Antigens [D12.776.395.550.448.130]
        
        CD59 Antigens [D12.776.395.550.448.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.395.550.448.150]
        
        Carbonic Anhydrase IV [D12.776.395.550.448.160]
        
        CD48 Antigen [D12.776.395.550.448.180]
        
        CD52 Antigen [D12.776.395.550.448.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.395.550.448.200]
        
        Contactins [D12.776.395.550.448.250]
        
        Ephrin-A1 [D12.776.395.550.448.300]
        
        Ephrin-A2 [D12.776.395.550.448.310]
        
        Ephrin-A3 [D12.776.395.550.448.320]
        
        Ephrin-A4 [D12.776.395.550.448.330]
        
        Ephrin-A5 [D12.776.395.550.448.340]
        
        Folate Receptors, GPI-Anchored [D12.776.395.550.448.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.395.550.448.400]
        
        Glypicans [D12.776.395.550.448.500]
        
        Mesothelin [D12.776.395.550.448.550]
        
        Prion Proteins [D12.776.395.550.448.600]
        
        Matrix Metalloproteinase 17 [D12.776.395.550.448.700]
        
        Nogo Receptors [D12.776.395.550.448.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.395.550.448.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.395.550.448.813]
        
        Uromodulin [D12.776.395.550.448.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Lipid-Linked Proteins [D12.776.543.484]
      - GPI-Linked Proteins [D12.776.543.484.500]
        
        Lipopolysaccharide Receptors [D12.776.543.484.500.100]
        
        CD24 Antigen [D12.776.543.484.500.120]
        
        CD55 Antigens [D12.776.543.484.500.130]
        
        CD59 Antigens [D12.776.543.484.500.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.543.484.500.150]
        
        Carbonic Anhydrase IV [D12.776.543.484.500.160]
        
        CD48 Antigen [D12.776.543.484.500.180]
        
        CD52 Antigen [D12.776.543.484.500.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.484.500.200]
        
        Contactins [D12.776.543.484.500.250]
        
        Ephrin-A1 [D12.776.543.484.500.300]
        
        Ephrin-A2 [D12.776.543.484.500.310]
        
        Ephrin-A3 [D12.776.543.484.500.320]
        
        Ephrin-A4 [D12.776.543.484.500.330]
        
        Ephrin-A5 [D12.776.543.484.500.340]
        
        Folate Receptors, GPI-Anchored [D12.776.543.484.500.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.484.500.400]
        
        Glypicans [D12.776.543.484.500.550]
        
        Mesothelin [D12.776.543.484.500.588]
        
        Prion Proteins [D12.776.543.484.500.625]
        
        Matrix Metalloproteinase 17 [D12.776.543.484.500.700]
        
        Nogo Receptors [D12.776.543.484.500.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.543.484.500.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.543.484.500.813]
        
        Uromodulin [D12.776.543.484.500.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - GPI-Linked Proteins [D12.776.543.550.418]
        
        Lipopolysaccharide Receptors [D12.776.543.550.418.100]
        
        CD24 Antigen [D12.776.543.550.418.120]
        
        CD55 Antigens [D12.776.543.550.418.130]
        
        CD59 Antigens [D12.776.543.550.418.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.543.550.418.150]
        
        Carbonic Anhydrase IV [D12.776.543.550.418.160]
        
        CD48 Antigen [D12.776.543.550.418.180]
        
        CD52 Antigen [D12.776.543.550.418.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.550.418.200]
        
        Contactins [D12.776.543.550.418.250]
        
        Ephrin-A1 [D12.776.543.550.418.300]
        
        Ephrin-A2 [D12.776.543.550.418.310]
        
        Ephrin-A3 [D12.776.543.550.418.320]
        
        Ephrin-A4 [D12.776.543.550.418.330]
        
        Ephrin-A5 [D12.776.543.550.418.340]
        
        Folate Receptors, GPI-Anchored [D12.776.543.550.418.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.550.418.400]
        
        Glypicans [D12.776.543.550.418.500]
        
        Mesothelin [D12.776.543.550.418.550]
        
        Prion Proteins [D12.776.543.550.418.600]
        
        Matrix Metalloproteinase 17 [D12.776.543.550.418.700]
        
        Nogo Receptors [D12.776.543.550.418.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.543.550.418.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.543.550.418.813]
        
        Uromodulin [D12.776.543.550.418.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.750.750.400.550.124]
        
        Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]
        
        Receptor, Nerve Growth Factor [D12.776.543.750.750.400.550.500]
        
        Receptor, trkA [D12.776.543.750.750.400.550.550]
        
        Receptor, trkB [D12.776.543.750.750.400.550.600]
        
        Receptor, trkC [D12.776.543.750.750.400.550.700]

Glial Cell Line-Derived Neurotrophic Factor Receptors Preferred

GFRA1 Receptor Narrower

Concept UI: M0479207
Terms: GFRA1 Receptor Preferred Term
Term UI T627531
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); GDNF Family Receptor Alpha 1
Term UI T627649
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); GDNF Family Receptor 1
Term UI T627650
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); Glial Derived Neurotrophic Factor Receptor 1
Term UI T627651
Date01/12/2005
LexicalTag NON
ThesaurusID NLM (2006)

GFRA2 Receptor Narrower

Concept UI: M0479208
Terms: GFRA2 Receptor Preferred Term
Term UI T627532
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); GDNF Family Receptor Alpha 2
Term UI T627652
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); GDNF Family Receptor 2
Term UI T627653
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); Glial Derived Neurotrophic Factor Receptor 2
Term UI T627654
Date01/12/2005
LexicalTag NON
ThesaurusID NLM (2006)

GFRA3 Receptor Narrower

Concept UI: M0479209
Terms: GFRA3 Receptor Preferred Term
Term UI T627533
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); GDNF Family Receptor 3
Term UI T316764
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); GDNF Family Receptor Alpha 3
Term UI T501861
Date06/28/2002
LexicalTag ACX
ThesaurusID NLM (2006); Glial Derived Neurotrophic Factor Receptor 3
Term UI T501862
Date06/28/2002
LexicalTag NON
ThesaurusID NLM (2006)

GFRA4 Receptor Narrower

Concept UI: M0479210
Terms: GFRA4 Receptor Preferred Term
Term UI T627534
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); Glial Derived Neurotrophic Factor Receptor 4
Term UI T627657
Date01/12/2005
LexicalTag NON
ThesaurusID NLM (2006); GDNF Family Receptor Alpha 4
Term UI T627655
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006); GDNF Family Receptor 4
Term UI T627656
Date01/12/2005
LexicalTag ACX
ThesaurusID NLM (2006)

Glial Cell Line-Derived Neurotrophic Factor Receptors MeSH Descriptor Data 2025