MeSH Browser

MeSH Heading: Tissue Inhibitor of Metalloproteinases
Tree Number(s): D12.776.815.875
Unique ID: D019714
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019714
Annotation: general or unspecified; prefer specifics
Scope Note: A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.
Entry Version: TISSUE INHIB METALLOPROTEINASES
Entry Term(s): TIMP Proteins; Tissue Inhibitor of Metalloproteinase
Pharm Action: Matrix Metalloproteinase Inhibitors
Previous Indexing: Enzyme Inhibitors (1989-1997); Glycoproteins (1980-1990)
Public MeSH Note: 98; COLLAGENASE INHIBITOR (now TISSUE INHIBITOR OF METALLOPROTEINASES) was indexed under GLYCOPROTEINS 1989-97 & ENZYME INHIBITORS 1980-90
History Note: 98; see TISSUE INHIBITOR OF METALLOPROTEINASES (NM) 1980-97
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2022/07/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Tissue Inhibitor of Metalloproteinases MeSH Descriptor Data 2025