ADP-Ribosylation Factors MeSH Descriptor Data 2025

MeSH Heading: ADP-Ribosylation Factors
Tree Number(s): D08.811.277.040.330.300.400.100; D12.776.157.325.515.100; D12.776.476.338.400.100
Unique ID: D020727
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020727
Scope Note: MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(ADP-RIBOSE) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. They are involved in vesicle trafficking and activation of PHOSPHOLIPASE D. This enzyme was formerly listed as EC 3.6.1.47
Entry Term(s): ADP-Ribosylation Factor; ARF Protein Cofactor
Previous Indexing: G-Proteins (1985-1999)
Public MeSH Note: 2000; ARF PROTEIN COFACTOR (now ADP-RIBOSYLATION FACTORS) was indexed under G-PROTEINS 1984-1999
History Note: 2000; use ADP-RIBOSYLATION FACTORS (NM) 1984-1999
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - GTP Phosphohydrolases [D08.811.277.040.330]
        
        GTP-Binding Proteins [D08.811.277.040.330.300]
        
        Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
        
        ADP-Ribosylation Factors [D08.811.277.040.330.300.400.100]
        
        ADP-Ribosylation Factor 6 [D08.811.277.040.330.300.400.100.050]
        
        ADP-Ribosylation Factor 1 [D08.811.277.040.330.300.400.100.100]
        
        rab GTP-Binding Proteins [D08.811.277.040.330.300.400.400]
        
        ral GTP-Binding Proteins [D08.811.277.040.330.300.400.450]
        
        ran GTP-Binding Protein [D08.811.277.040.330.300.400.462]
        
        rap GTP-Binding Proteins [D08.811.277.040.330.300.400.475]
        
        Ras Homolog Enriched in Brain Protein [D08.811.277.040.330.300.400.488]
        
        ras Proteins [D08.811.277.040.330.300.400.500]
        
        rho GTP-Binding Proteins [D08.811.277.040.330.300.400.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - GTP-Binding Proteins [D12.776.157.325]
      - Monomeric GTP-Binding Proteins [D12.776.157.325.515]
        
        ADP-Ribosylation Factors [D12.776.157.325.515.100]
        
        ADP-Ribosylation Factor 1 [D12.776.157.325.515.100.100]
        
        ADP-Ribosylation Factor 6 [D12.776.157.325.515.100.550]
        
        rab GTP-Binding Proteins [D12.776.157.325.515.400]
        
        ral GTP-Binding Proteins [D12.776.157.325.515.450]
        
        ran GTP-Binding Protein [D12.776.157.325.515.462]
        
        rap GTP-Binding Proteins [D12.776.157.325.515.475]
        
        Ras Homolog Enriched in Brain Protein [D12.776.157.325.515.488]
        
        ras Proteins [D12.776.157.325.515.500]
        
        rho GTP-Binding Proteins [D12.776.157.325.515.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - GTP-Binding Proteins [D12.776.476.338]
      - Monomeric GTP-Binding Proteins [D12.776.476.338.400]
        
        ADP-Ribosylation Factors [D12.776.476.338.400.100]
        
        ADP-Ribosylation Factor 6 [D12.776.476.338.400.100.050]
        
        ADP-Ribosylation Factor 1 [D12.776.476.338.400.100.100]
        
        rab GTP-Binding Proteins [D12.776.476.338.400.400]
        
        ral GTP-Binding Proteins [D12.776.476.338.400.450]
        
        ran GTP-Binding Protein [D12.776.476.338.400.462]
        
        rap GTP-Binding Proteins [D12.776.476.338.400.475]
        
        Ras Homolog Enriched in Brain Protein [D12.776.476.338.400.488]
        
        ras Proteins [D12.776.476.338.400.500]
        
        rho GTP-Binding Proteins [D12.776.476.338.400.700]

ADP-Ribosylation Factors Preferred

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