MeSH Browser

MeSH Heading: Complementarity Determining Regions
Tree Number(s): D12.644.541.500.650.500.180; D12.776.124.486.485.680.650.500.180; D12.776.124.486.485.797.180; D12.776.124.790.651.680.650.500.180; D12.776.124.790.651.797.180; D12.776.377.715.548.680.650.500.180; D12.776.377.715.548.797.180; D12.776.543.750.705.816.824.300; G02.111.570.060.425.160
Unique ID: D022801
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D022801
Scope Note: Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Entry Term(s): Complementarity Determining Region; Complementarity Determining Region 1; Complementarity Determining Region 2; Complementarity Determining Region 3; Complementarity Determining Region I; Complementarity Determining Region II; Complementarity Determining Region III; Complementarity-Determining Region; Complementarity-Determining Region 3; Hypervariable Region, Immunoglobulin; Hypervariable Regions, Immunoglobulin; Third Complementarity-Determining Region
Previous Indexing: Immunoglobulin Variable Region (1982-2000)
See Also: Receptors, Antigen, T-Cell
Public MeSH Note: 2001; for COMPLEMENTARITY DETERMINING REGION and HYPERVARIABLE REGION see IMMUNOGLOBULIN VARIABLE REGION 1988-2000; COMPLEMENTARITY-DETERMINING REGION 3 was indexed under COMPLEMENTARITY DETERMINING REGIONS 1998-2005
History Note: 2001; for COMPLEMENTARITY DETERMINING REGION and HYPERVARIABLE REGION use IMMUNOGLOBULIN VARIABLE REGION 1988-2000
Date Established: 2001/01/01
Date of Entry: 2000/06/22
Revision Date: 2011/06/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Fragments [D12.644.541]
    - Immunoglobulin Fragments [D12.644.541.500]
      - Immunoglobulin Fab Fragments [D12.644.541.500.650]
        
        Immunoglobulin Variable Region [D12.644.541.500.650.500]
        
        Complementarity Determining Regions [D12.644.541.500.650.500.180]
        
        Immunoglobulin Joining Region [D12.644.541.500.650.500.590]
        
        Single-Chain Antibodies [D12.644.541.500.650.500.800]
        
        Single-Domain Antibodies [D12.644.541.500.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Fragments [D12.776.124.486.485.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
        
        Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.486.485.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.486.485.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.486.485.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.486.485.680.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Variable Region [D12.776.124.486.485.797]
        
        Complementarity Determining Regions [D12.776.124.486.485.797.180]
        
        Immunoglobulin Joining Region [D12.776.124.486.485.797.590]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Fragments [D12.776.124.790.651.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
        
        Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
        
        Complementarity Determining Regions [D12.776.124.790.651.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.124.790.651.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.124.790.651.680.650.500.800]
        
        Single-Domain Antibodies [D12.776.124.790.651.680.650.500.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Variable Region [D12.776.124.790.651.797]
        
        Complementarity Determining Regions [D12.776.124.790.651.797.180]
        
        Immunoglobulin Joining Region [D12.776.124.790.651.797.590]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Fragments [D12.776.377.715.548.680]
        
        Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
        
        Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
        
        Complementarity Determining Regions [D12.776.377.715.548.680.650.500.180]
        
        Immunoglobulin Joining Region [D12.776.377.715.548.680.650.500.590]
        
        Single-Chain Antibodies [D12.776.377.715.548.680.650.500.795]
        
        Single-Domain Antibodies [D12.776.377.715.548.680.650.500.897]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Variable Region [D12.776.377.715.548.797]
        
        Complementarity Determining Regions [D12.776.377.715.548.797.180]
        
        Immunoglobulin Joining Region [D12.776.377.715.548.797.590]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Antigen [D12.776.543.750.705.816]
        
        Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]
        
        Receptors, Chimeric Antigen [D12.776.543.750.705.816.824.150]
        
        Complementarity Determining Regions [D12.776.543.750.705.816.824.300]
        
        Receptor-CD3 Complex, Antigen, T-Cell [D12.776.543.750.705.816.824.800]
        
        Receptors, Antigen, T-Cell, alpha-beta [D12.776.543.750.705.816.824.825]
        
        Receptors, Antigen, T-Cell, gamma-delta [D12.776.543.750.705.816.824.830]

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Amino Acid Sequence [G02.111.570.060]
      - Immunoglobulin Variable Region [G02.111.570.060.425]
        
        Binding Sites, Antibody [G02.111.570.060.425.079]
        
        Complementarity Determining Regions [G02.111.570.060.425.160]
        
        Immunoglobulin Idiotypes [G02.111.570.060.425.580]

Complementarity Determining Regions Preferred

Concept UI: M0359304
Scope Note: Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Terms: Complementarity Determining Regions Preferred Term
Term UI T410114
Date03/22/2000
LexicalTag NON
ThesaurusID NLM (2001); Complementarity Determining Region
Term UI T021356
Date03/15/1991
LexicalTag NON
ThesaurusID NLM (1992); Complementarity-Determining Region
Term UI T021357
Date05/11/1987
LexicalTag NON
ThesaurusID UNK (19XX); Hypervariable Region, Immunoglobulin
Term UI T759737
Date10/20/2009
LexicalTag NON
ThesaurusID NLM (2011); Hypervariable Regions, Immunoglobulin
Term UI T759861
Date10/22/2009
LexicalTag NON
ThesaurusID NLM (2011)

Complementarity Determining Region 1 Narrower

Complementarity Determining Region 2 Narrower

Complementarity Determining Region 3 Narrower

Complementarity Determining Regions MeSH Descriptor Data 2025