HIV Reverse Transcriptase MeSH Descriptor Data 2025

MeSH Heading: HIV Reverse Transcriptase
Tree Number(s): D08.811.913.696.445.308.300.750.187; D12.776.964.775.375.545.875; D12.776.964.775.375.750.187; D12.776.964.775.562.764.875; D12.776.964.900.750.500.545.875; D12.776.964.900.750.500.750.187; D12.776.964.970.600.850.375.545.875; D12.776.964.970.600.850.375.750.187
Unique ID: D054303
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054303
Scope Note: A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.
Entry Term(s): Reverse Transcriptase, HIV; Reverse Transcriptase, Human Immunodeficiency Virus
Registry Numbers: EC 2.7.7.49
Previous Indexing: RNA-Directed DNA Polymerase (1983-2007)
Public MeSH Note: 2008
History Note: 2008
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Nucleotidyltransferases [D08.811.913.696.445]
        
        DNA Nucleotidyltransferases [D08.811.913.696.445.308]
        
        DNA-Directed DNA Polymerase [D08.811.913.696.445.308.300]
        
        RNA-Directed DNA Polymerase [D08.811.913.696.445.308.300.750]
        
        HIV Reverse Transcriptase [D08.811.913.696.445.308.300.750.187]
        
        Telomerase [D08.811.913.696.445.308.300.750.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Retroviridae Proteins [D12.776.964.775]
      - Gene Products, pol [D12.776.964.775.375]
        
        pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.375.545]
        
        HIV Integrase [D12.776.964.775.375.545.500]
        
        HIV Protease [D12.776.964.775.375.545.750]
        
        HIV Reverse Transcriptase [D12.776.964.775.375.545.875]
        
        Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.775.375.545.875.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Retroviridae Proteins [D12.776.964.775]
      - Gene Products, pol [D12.776.964.775.375]
        
        RNA-Directed DNA Polymerase [D12.776.964.775.375.750]
        
        HIV Reverse Transcriptase [D12.776.964.775.375.750.187]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Retroviridae Proteins [D12.776.964.775]
      - Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
        
        pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.764]
        
        HIV Integrase [D12.776.964.775.562.764.500]
        
        HIV Reverse Transcriptase [D12.776.964.775.562.764.875]
        
        Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.775.562.764.875.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Viral Nonstructural Proteins [D12.776.964.900]
      - Viral Replicase Complex Proteins [D12.776.964.900.750]
        
        Gene Products, pol [D12.776.964.900.750.500]
        
        pol Gene Products, Human Immunodeficiency Virus [D12.776.964.900.750.500.545]
        
        HIV Integrase [D12.776.964.900.750.500.545.500]
        
        HIV Reverse Transcriptase [D12.776.964.900.750.500.545.875]
        
        Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.900.750.500.545.875.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Viral Nonstructural Proteins [D12.776.964.900]
      - Viral Replicase Complex Proteins [D12.776.964.900.750]
        
        Gene Products, pol [D12.776.964.900.750.500]
        
        RNA-Directed DNA Polymerase [D12.776.964.900.750.500.750]
        
        HIV Reverse Transcriptase [D12.776.964.900.750.500.750.187]
        
        Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.900.750.500.750.187.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Viral Structural Proteins [D12.776.964.970]
      - Nucleocapsid Proteins [D12.776.964.970.600]
        
        Viral Core Proteins [D12.776.964.970.600.850]
        
        Gene Products, pol [D12.776.964.970.600.850.375]
        
        pol Gene Products, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545]
        
        HIV Integrase [D12.776.964.970.600.850.375.545.500]
        
        HIV Reverse Transcriptase [D12.776.964.970.600.850.375.545.875]
        
        Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545.875.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Viral Structural Proteins [D12.776.964.970]
      - Nucleocapsid Proteins [D12.776.964.970.600]
        
        Viral Core Proteins [D12.776.964.970.600.850]
        
        Gene Products, pol [D12.776.964.970.600.850.375]
        
        RNA-Directed DNA Polymerase [D12.776.964.970.600.850.375.750]
        
        HIV Reverse Transcriptase [D12.776.964.970.600.850.375.750.187]
        
        Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.750.187.500]

HIV Reverse Transcriptase Preferred

Concept UI: M0503898
Registry Numbers: EC 2.7.7.49
Scope Note: A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.
Terms: HIV Reverse Transcriptase Preferred Term
Term UI T685993
Date11/14/2006
LexicalTag ABX
ThesaurusID NLM (2008); Reverse Transcriptase, HIV
Term UI T685994
Date11/14/2006
LexicalTag ABX
ThesaurusID NLM (2008); Reverse Transcriptase, Human Immunodeficiency Virus
Term UI T685995
Date11/14/2006
LexicalTag NON
ThesaurusID NLM (2008)

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