Calcium Release Activated Calcium Channels MeSH Descriptor Data 2025

MeSH Heading: Calcium Release Activated Calcium Channels
Tree Number(s): D12.776.157.530.400.150.740; D12.776.543.550.450.150.740; D12.776.543.585.400.150.740
Unique ID: D000071739
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071739
Scope Note: Specialized calcium channels that localize to the ENDOPLAMSIC RETICULUM and PLASMA MEMBRANE. They contain the pore subunit ORAI1 PROTEIN which is activated by STROMAL INTERACTION MOLECULES upon intracellular calcium depletion.
Entry Term(s): CRAC Channel; CRAC Channels; Calcium Release Activated Calcium Channel; Calcium Release-Activated Calcium Channels; Calcium Release-Activated Channels
Previous Indexing: Calcium Channels (1995-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Calcium Channels [D12.776.157.530.400.150]
        
        Calcium Channels, L-Type [D12.776.157.530.400.150.400]
        
        Calcium Channels, N-Type [D12.776.157.530.400.150.585]
        
        Calcium Channels, T-Type [D12.776.157.530.400.150.720]
        
        Calcium Release Activated Calcium Channels [D12.776.157.530.400.150.740]
        
        ORAI1 Protein [D12.776.157.530.400.150.740.500]
        
        ORAI2 Protein [D12.776.157.530.400.150.740.750]
        
        Inositol 1,4,5-Trisphosphate Receptors [D12.776.157.530.400.150.760]
        
        Ryanodine Receptor Calcium Release Channel [D12.776.157.530.400.150.800]
        
        TRPC6 Cation Channel [D12.776.157.530.400.150.850]
        
        TRPP Cation Channels [D12.776.157.530.400.150.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Calcium Channels [D12.776.543.550.450.150]
        
        Calcium Channels, L-Type [D12.776.543.550.450.150.400]
        
        Calcium Channels, N-Type [D12.776.543.550.450.150.585]
        
        Calcium Channels, T-Type [D12.776.543.550.450.150.720]
        
        Calcium Release Activated Calcium Channels [D12.776.543.550.450.150.740]
        
        ORAI1 Protein [D12.776.543.550.450.150.740.500]
        
        ORAI2 Protein [D12.776.543.550.450.150.740.750]
        
        Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.550.450.150.760]
        
        Ryanodine Receptor Calcium Release Channel [D12.776.543.550.450.150.800]
        
        TRPC6 Cation Channel [D12.776.543.550.450.150.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Calcium Channels [D12.776.543.585.400.150]
        
        Calcium Channels, L-Type [D12.776.543.585.400.150.400]
        
        Calcium Channels, N-Type [D12.776.543.585.400.150.585]
        
        Calcium Channels, T-Type [D12.776.543.585.400.150.720]
        
        Calcium Release Activated Calcium Channels [D12.776.543.585.400.150.740]
        
        ORAI1 Protein [D12.776.543.585.400.150.740.500]
        
        ORAI2 Protein [D12.776.543.585.400.150.740.750]
        
        Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.585.400.150.760]
        
        Ryanodine Receptor Calcium Release Channel [D12.776.543.585.400.150.800]
        
        TRPC6 Cation Channel [D12.776.543.585.400.150.850]
        
        TRPP Cation Channels [D12.776.543.585.400.150.900]

Calcium Release Activated Calcium Channels Preferred

page delivered in 0.16s