TRPC6 Cation Channel MeSH Descriptor Data 2025

MeSH Heading: TRPC6 Cation Channel
Tree Number(s): D12.776.157.530.400.150.850; D12.776.157.530.400.901.500.500; D12.776.543.550.450.150.900; D12.776.543.585.400.150.850; D12.776.543.585.400.901.500.500
Unique ID: D000074287
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074287
Scope Note: A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
Entry Term(s): TRPC6; Transient Receptor Potential Cation Channel Subfamily C, Member 6
Previous Indexing: Calcium Channels (1999-2017); TRPC Cation Channels (2006-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Calcium Channels [D12.776.157.530.400.150]
        
        Calcium Channels, L-Type [D12.776.157.530.400.150.400]
        
        Calcium Channels, N-Type [D12.776.157.530.400.150.585]
        
        Calcium Channels, T-Type [D12.776.157.530.400.150.720]
        
        Calcium Release Activated Calcium Channels [D12.776.157.530.400.150.740]
        
        Inositol 1,4,5-Trisphosphate Receptors [D12.776.157.530.400.150.760]
        
        Ryanodine Receptor Calcium Release Channel [D12.776.157.530.400.150.800]
        
        TRPC6 Cation Channel [D12.776.157.530.400.150.850]
        
        TRPP Cation Channels [D12.776.157.530.400.150.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Transient Receptor Potential Channels [D12.776.157.530.400.901]
        
        TRPC Cation Channels [D12.776.157.530.400.901.500]
        
        TRPC6 Cation Channel [D12.776.157.530.400.901.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Calcium Channels [D12.776.543.550.450.150]
        
        Calcium Channels, L-Type [D12.776.543.550.450.150.400]
        
        Calcium Channels, N-Type [D12.776.543.550.450.150.585]
        
        Calcium Channels, T-Type [D12.776.543.550.450.150.720]
        
        Calcium Release Activated Calcium Channels [D12.776.543.550.450.150.740]
        
        Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.550.450.150.760]
        
        Ryanodine Receptor Calcium Release Channel [D12.776.543.550.450.150.800]
        
        TRPC6 Cation Channel [D12.776.543.550.450.150.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Calcium Channels [D12.776.543.585.400.150]
        
        Calcium Channels, L-Type [D12.776.543.585.400.150.400]
        
        Calcium Channels, N-Type [D12.776.543.585.400.150.585]
        
        Calcium Channels, T-Type [D12.776.543.585.400.150.720]
        
        Calcium Release Activated Calcium Channels [D12.776.543.585.400.150.740]
        
        Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.585.400.150.760]
        
        Ryanodine Receptor Calcium Release Channel [D12.776.543.585.400.150.800]
        
        TRPC6 Cation Channel [D12.776.543.585.400.150.850]
        
        TRPP Cation Channels [D12.776.543.585.400.150.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Transient Receptor Potential Channels [D12.776.543.585.400.901]
        
        TRPC Cation Channels [D12.776.543.585.400.901.500]
        
        TRPC6 Cation Channel [D12.776.543.585.400.901.500.500]

TRPC6 Cation Channel Preferred

Concept UI: M000625933
Scope Note: A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
Terms: TRPC6 Cation Channel Preferred Term
Term UI T000914734
Date01/26/2017
LexicalTag NON
ThesaurusID NLM (2018); TRPC6
Term UI T000914735
Date01/26/2017
LexicalTag ABB
ThesaurusID NLM (2018); Transient Receptor Potential Cation Channel Subfamily C, Member 6
Term UI T000914736
Date01/26/2017
LexicalTag NON
ThesaurusID NLM (2018)

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