MeSH Browser

MeSH Heading: Patched-1 Receptor
Tree Number(s): D12.776.543.750.058.500; D12.776.624.776.633.500
Unique ID: D000072081
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072081
Scope Note: A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.
Entry Term(s): PTCH1 Protein; Patched Homolog-1; Patched Receptor-1; Patched-1 Protein
Public MeSH Note: 2017; PATCHED-1 RECEPTOR was indexed under RECEPTORS, CELL SURFACE 2005-2016, and under MEMBRANE PROTEINS 1996-2005
History Note: 2017 (1996)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M000616305
Scope Note: A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.
Terms: Patched-1 Receptor Preferred Term
Term UI T000898000
Date03/31/2016
LexicalTag NON
ThesaurusID NLM (2017); Patched Receptor-1
Term UI T000900483
Date05/06/2016
LexicalTag NON
ThesaurusID NLM (2017); PTCH1 Protein
Term UI T000900484
Date05/06/2016
LexicalTag ABX
ThesaurusID NLM (2017); Patched-1 Protein
Term UI T000898001
Date03/31/2016
LexicalTag NON
ThesaurusID NLM (2017); Patched Homolog-1
Term UI T000898004
Date03/31/2016
LexicalTag NON
ThesaurusID NLM (2017)

Patched-1 Receptor MeSH Descriptor Data 2025