MeSH Browser

MeSH Heading: Patched-2 Receptor
Tree Number(s): D12.776.543.750.058.750; D12.776.624.776.633.750
Unique ID: D000072082
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072082
Scope Note: A patched receptor that may function redundantly with the PATCHED-1 RECEPTOR to modulate hedgehog signaling. It may also play a role in epidermal development and as a TUMOR SUPPRESSOR PROTEIN. Mutations in the patched-2 gene are associated with BASAL CELL NEVUS SYNDROME; CARCINOMA, BASAL CELL; and MEDULLOBLASTOMA.
Entry Term(s): PTCH2 Protein; Patched Homolog-2; Patched Receptor-2; Patched-2 Protein
Registry Numbers: 0
Public MeSH Note: 2017; 2017; PATCHED-2 RECEPTOR was indexed under RECEPTORS, CELL SURFACE 2005-2016, and under MEMBRANE PROTEINS 1996-2005
History Note: 2017 (1996)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M000616307
Registry Numbers: 0
Scope Note: A patched receptor that may function redundantly with the PATCHED-1 RECEPTOR to modulate hedgehog signaling. It may also play a role in epidermal development and as a TUMOR SUPPRESSOR PROTEIN. Mutations in the patched-2 gene are associated with BASAL CELL NEVUS SYNDROME; CARCINOMA, BASAL CELL; and MEDULLOBLASTOMA.
Terms: Patched-2 Receptor Preferred Term
Term UI T000898006
Date03/31/2016
LexicalTag NON
ThesaurusID NLM (2017); Patched-2 Protein
Term UI T000898009
Date03/31/2016
LexicalTag NON
ThesaurusID NLM (2017); Patched Homolog-2
Term UI T000898010
Date03/31/2016
LexicalTag NON
ThesaurusID NLM (2017); Patched Receptor-2
Term UI T000900487
Date05/06/2016
LexicalTag NON
ThesaurusID NLM (2017); PTCH2 Protein
Term UI T000900488
Date05/06/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Patched-2 Receptor MeSH Descriptor Data 2025