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Pregnane X Receptor MeSH Descriptor Data 2023


MeSH Heading
Pregnane X Receptor
Tree Number(s)
D12.776.826.750.075
D12.776.930.778.175
Unique ID
D000077297
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077297
Scope Note
Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Entry Term(s)
NR1I2
Nuclear Receptor Subfamily 1, Group I, Member 2
SXR Receptor
Steroid X Receptor
Steroid and Xenobiotic Receptor
Registry Number
0
Public MeSH Note
2019; PREGNANE X RECEPTOR was indexed under RECEPTORS, STEROID 2007-2018; and under RECEPTORS, CYTOPLASMIC AND NUCLEAR 1998-2006
History Note
2019 (1998)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/02/28
Pregnane X Receptor Preferred
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