MeSH Browser

MeSH Heading: Angiotensin-Converting Enzyme 2
Tree Number(s): D08.811.277.656.350.245.042
Unique ID: D000085962
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000085962
Scope Note: A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.
Entry Term(s): ACE-Related Carboxypeptidase; ACE2 Angiotensin-Converting Enzyme Protein 2; ACE2 Enzyme; ACE2 Protein; Angiotensin Converting Enzyme 2; Angiotensin-Converting Enzyme-Related Carboxypeptidase
Public MeSH Note: 2021; ACE2 ENZYME was indexed as CARBOXYPEPTIDASES 2000-2006; and PEPTIDYL-DIPEPTIDASE A 2007-2020
History Note: 2021 (2000)
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/06/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0370114
Scope Note: A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.
Terms: Angiotensin-Converting Enzyme 2 Preferred Term
Term UI T001078344
Date04/10/2020
LexicalTag NON
ThesaurusID NLM (2021); Angiotensin-Converting Enzyme-Related Carboxypeptidase
Term UI T001078348
Date04/10/2020
LexicalTag NON
ThesaurusID NLM (2021); Angiotensin Converting Enzyme 2
Term UI T001078349
Date04/10/2020
LexicalTag NON
ThesaurusID NLM (2021); ACE2 Enzyme
Term UI T001078347
Date04/10/2020
LexicalTag ACX
ThesaurusID NLM (2021); ACE2 Angiotensin-Converting Enzyme Protein 2
Term UI T001078626
Date04/15/2020
LexicalTag NON
ThesaurusID NLM (2021); ACE-Related Carboxypeptidase
Term UI T001078346
Date04/10/2020
LexicalTag ACX
ThesaurusID NLM (2021); ACE2 Protein
Term UI T001078624
Date04/15/2020
LexicalTag NON
ThesaurusID NLM (2021)

Angiotensin-Converting Enzyme 2 MeSH Descriptor Data 2025