Lysine Carboxypeptidase MeSH Descriptor Data 2025

MeSH Heading: Lysine Carboxypeptidase
Tree Number(s): D08.811.277.656.350.245.450; D08.811.277.656.350.555.750; D08.811.277.656.675.555.750
Unique ID: D001121
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001121
Scope Note: A metallocarboxypeptidase that removes C-terminal basic amino acid from peptides and proteins, with preference shown for lysine over arginine. It is a plasma zinc enzyme that inactivates bradykinin and anaphylatoxins.
Entry Term(s): Anaphylatoxin Inactivator; Bradykininase; Carboxypeptidase N; Kininase I
Previous Indexing: Arginine (1972-1974); Carboxypeptidases (1972-1974); Peptides (1972-1974)
Public MeSH Note: 1997; see ARGININE CARBOXYPEPTIDASE 1991-1996, see CARBOXYPEPTIDASES 1975-1990; for KININASE I see CARBOXYPEPTIDASES 1975-1981
History Note: 1997 (1975)
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Exopeptidases [D08.811.277.656.350]
        
        Carboxypeptidases [D08.811.277.656.350.245]
        
        Angiotensin-Converting Enzyme 2 [D08.811.277.656.350.245.042]
        
        Carboxypeptidase B [D08.811.277.656.350.245.083]
        
        Carboxypeptidase B2 [D08.811.277.656.350.245.125]
        
        Carboxypeptidase H [D08.811.277.656.350.245.167]
        
        Carboxypeptidases A [D08.811.277.656.350.245.250]
        
        Cathepsin A [D08.811.277.656.350.245.260]
        
        Cathepsin Z [D08.811.277.656.350.245.270]
        
        gamma-Glutamyl Hydrolase [D08.811.277.656.350.245.280]
        
        Glutamate Carboxypeptidase II [D08.811.277.656.350.245.400]
        
        Lysine Carboxypeptidase [D08.811.277.656.350.245.450]
        
        Muramoylpentapeptide Carboxypeptidase [D08.811.277.656.350.245.500]
        
        Serine-Type D-Ala-D-Ala Carboxypeptidase [D08.811.277.656.350.245.800]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Exopeptidases [D08.811.277.656.350]
        
        Metalloexopeptidases [D08.811.277.656.350.555]
        
        CD13 Antigens [D08.811.277.656.350.555.100]
        
        Carboxypeptidase B [D08.811.277.656.350.555.200]
        
        Carboxypeptidase B2 [D08.811.277.656.350.555.225]
        
        Carboxypeptidase H [D08.811.277.656.350.555.250]
        
        Carboxypeptidases A [D08.811.277.656.350.555.350]
        
        Cystinyl Aminopeptidase [D08.811.277.656.350.555.400]
        
        Glutamate Carboxypeptidase II [D08.811.277.656.350.555.500]
        
        Glutamyl Aminopeptidase [D08.811.277.656.350.555.600]
        
        Leucyl Aminopeptidase [D08.811.277.656.350.555.700]
        
        Lysine Carboxypeptidase [D08.811.277.656.350.555.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloexopeptidases [D08.811.277.656.675.555]
        
        CD13 Antigens [D08.811.277.656.675.555.100]
        
        Carboxypeptidase B [D08.811.277.656.675.555.200]
        
        Carboxypeptidase B2 [D08.811.277.656.675.555.225]
        
        Carboxypeptidase H [D08.811.277.656.675.555.250]
        
        Carboxypeptidases A [D08.811.277.656.675.555.350]
        
        Cystinyl Aminopeptidase [D08.811.277.656.675.555.400]
        
        Glutamate Carboxypeptidase II [D08.811.277.656.675.555.500]
        
        Glutamyl Aminopeptidase [D08.811.277.656.675.555.600]
        
        Leucyl Aminopeptidase [D08.811.277.656.675.555.700]
        
        Lysine Carboxypeptidase [D08.811.277.656.675.555.750]

Lysine Carboxypeptidase Preferred

Concept UI: M0001685
Scope Note: A metallocarboxypeptidase that removes C-terminal basic amino acid from peptides and proteins, with preference shown for lysine over arginine. It is a plasma zinc enzyme that inactivates bradykinin and anaphylatoxins.
Terms: Lysine Carboxypeptidase Preferred Term
Term UI T003393
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Anaphylatoxin Inactivator
Term UI T003387
Date08/12/1987
LexicalTag NON
ThesaurusID UNK (19XX); Bradykininase
Term UI T003390
Date02/17/1983
LexicalTag NON
ThesaurusID UNK (19XX); Carboxypeptidase N
Term UI T003391
Date05/12/1981
LexicalTag NON
ThesaurusID UNK (19XX); Kininase I
Term UI T003392
Date05/12/1981
LexicalTag NON
ThesaurusID UNK (19XX)

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