MeSH Browser

MeSH Heading: Tripeptidyl-Peptidase 1
Tree Number(s): D08.811.277.656.350.100.877; D08.811.277.656.350.350.843; D08.811.277.656.959.780
Unique ID: D000091346
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000091346
Scope Note: Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.
Entry Term(s): CLN2 Protein; TPP1 Protein; Tripeptidyl Aminopeptidase I; Tripeptidyl Peptidase I; Tripeptidyl Protease I; Tripeptidyl-Peptidase I
Related Numbers: EC 3.4.14.9
Public MeSH Note: 2022; TRIPEPTIDYL-PEPTIDASES 1 was indexed under AMINOPEPTIDASES, DIPEPTIDYL-PEPTIDYL-PEPTIDASES and under SERINE PROTEASES 1995-2021
History Note: 2022 (1993)
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2022/04/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000748625
Related Numbers: EC 3.4.14.9
Scope Note: Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.
Terms: Tripeptidyl-Peptidase 1 Preferred Term
Term UI T001106517
Date05/17/2021
LexicalTag NON
ThesaurusID NLM (2022); TPP1 Protein
Term UI T001107661
Date06/08/2021
LexicalTag ABX
ThesaurusID NLM (2022); CLN2 Protein
Term UI T001107662
Date06/08/2021
LexicalTag ABX
ThesaurusID NLM (2022); Tripeptidyl Aminopeptidase I
Term UI T001106518
Date05/17/2021
LexicalTag NON
ThesaurusID NLM (2022); Tripeptidyl Protease I
Term UI T001106519
Date05/17/2021
LexicalTag NON
ThesaurusID NLM (2022); Tripeptidyl-Peptidase I
Term UI T001106520
Date05/17/2021
LexicalTag NON
ThesaurusID NLM (2022); Tripeptidyl Peptidase I
Term UI T001106521
Date05/17/2021
LexicalTag NON
ThesaurusID NLM (2022)

Tripeptidyl-Peptidase 1 MeSH Descriptor Data 2025