MeSH Browser

MeSH Heading: Cathepsin C
Tree Number(s): D08.811.277.656.224.130; D08.811.277.656.262.186; D08.811.277.656.350.350.100
Unique ID: D020789
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020789
Scope Note: A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.
Entry Term(s): Dipeptidyl Aminopeptidase I; Dipeptidyl Peptidase I; Dipeptidyl Transferase
Previous Indexing: Dipeptidyl Peptidases (1984-1999)
Public MeSH Note: 2010; see DIPEPTIDYL PEPTIDASE I 2000-2009; DIPEPTIDYL PEPTIDASE I was indexed under DIPEPTIDYL PEPTIDASES 1984-1999; CATHEPSINS 1981-1984
History Note: 2010(1981)
Date Established: 2000/01/01
Date of Entry: 1999/11/05
Revision Date: 2010/06/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0262814
Scope Note: A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.
Terms: Cathepsin C Preferred Term
Term UI T292816
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Dipeptidyl Aminopeptidase I
Term UI T292817
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Dipeptidyl Peptidase I
Term UI T292819
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Dipeptidyl Transferase
Term UI T292818
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

Cathepsin C MeSH Descriptor Data 2025