MeSH Browser

MeSH Heading: Chediak-Higashi Syndrome
Tree Number(s): C11.270.040.772; C15.378.553.774.257; C16.320.798.375; C20.673.774.257; C20.673.795.375
Unique ID: D002609
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002609
Scope Note: A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.
Entry Term(s): Chediak-Steinbrinck-Higashi Syndrome; Oculocutaneous Albinism with Leukocyte Defect
NLM Classification #: QW 740
Previous Indexing: Immunologic Deficiency Syndromes (1968-1970); Leukocytes (1966-1970)
See Also: Aleutian Mink Disease
Public MeSH Note: 71
History Note: 71
Date Established: 1971/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/06/17

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0003997
Scope Note: A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.
Terms: Chediak-Higashi Syndrome Preferred Term
Term UI T007597
Date01/01/1999
LexicalTag EPO
ThesaurusID; Chediak-Steinbrinck-Higashi Syndrome
Term UI T841104
Date04/18/2013
LexicalTag NON
ThesaurusID; Oculocutaneous Albinism with Leukocyte Defect
Term UI T841105
Date04/18/2013
LexicalTag NON
ThesaurusID

Chediak-Higashi Syndrome MeSH Descriptor Data 2025