MeSH Browser

MeSH Heading: Immunoglobulin Switch Region
Tree Number(s): G05.360.340.024.340.137.430; G05.360.340.024.340.335.300.500
Unique ID: D007134
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007134
Scope Note: A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
Entry Version: IG SWITCH REGION
Entry Term(s): Heavy-Chain Mu Switch Region; Ig Switch Region; Ig Switch Sequences; Switch Region, Immunoglobulin
Previous Indexing: Genes, Structural (1977-1987); Immunoglobulin Constant Region (1979-1987); Immunoglobulin Variable Region (1977-1987)
See Also: Immunoglobulin Class Switching
Public MeSH Note: 88
History Note: 88
Date Established: 1988/01/01
Date of Entry: 1987/05/11
Revision Date: 2019/07/05

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

isolation & purification (IP)

physiology (PH)

radiation effects (RE)

Concept UI: M0011115
Scope Note: A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
Terms: Immunoglobulin Switch Region Preferred Term
Term UI T021353
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1988); Switch Region, Immunoglobulin
Term UI T021352
Date05/11/1987
LexicalTag NON
ThesaurusID UNK (19XX); Ig Switch Sequences
Term UI T021351
Date06/07/1988
LexicalTag NON
ThesaurusID UNK (19XX); Ig Switch Region
Term UI T000952314
Date03/01/2019
LexicalTag NON
ThesaurusID NLM (2020)

Immunoglobulin Switch Region MeSH Descriptor Data 2023